Higashi Sayuri L, Ikeda Masato
United Graduate School of Drug Discovery and Medical Information Sciences, Gifu University, 1-1 Yanagido, Gifu 501-1193, Japan.
Department of Chemistry and Biomolecular Science, Faculty of Engineering, Gifu University, 1-1 Yanagido, Gifu 501-1193, Japan.
JACS Au. 2021 Jul 22;1(10):1639-1646. doi: 10.1021/jacsau.1c00270. eCollection 2021 Oct 25.
Stimuli-responsive supramolecular hydrogels are a newly emerging class of aqueous soft materials with a wide variety of bioapplications. Here we report a reduction-responsive supramolecular hydrogel constructed from a markedly simple low-molecular-weight hydrogelator, which is developed on the basis of modular molecular design containing a hydrophilic amino sugar and a reduction-responsive nitrophenyl group. The hydrogel formation ability differs significantly between glucosamine- and galactosamine-based self-assembling molecules, which are epimers at the C4 position, and only the glucosamine-based derivative can act as a hydrogelator.
刺激响应性超分子水凝胶是一类新兴的水性软材料，具有广泛的生物应用。在此，我们报道了一种由极其简单的低分子量水凝胶剂构建的还原响应性超分子水凝胶，该水凝胶剂是基于包含亲水性氨基糖和还原响应性硝基苯基的模块化分子设计开发的。基于葡萄糖胺和半乳糖胺的自组装分子在C4位置为差向异构体，它们形成水凝胶的能力存在显著差异，只有基于葡萄糖胺的衍生物可以作为水凝胶剂。
