Department of Chemistry, College of Science, Shanghai University, Shanghai 200444, China.
State Key Laboratory of High Performance Ceramics and Superfine Microstructures, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, 200050, China.
Nanoscale. 2021 Nov 11;13(43):18300-18310. doi: 10.1039/d1nr05449j.
Photothermal therapy has been considered a powerful means of cancer therapy due to its minimal invasiveness, effectiveness, and convenience. Although promising, the therapeutic effects are greatly limited as they rely on the photothermal agent (PTA). It is urgent to develop new PTAs with high photothermal conversion performance, especially under irradiation in the long-wavelength biowindows. Herein, a dual-biowindow-responsive PTA made of NbS-PVP nanosheets was fabricated to be used both in the first near-infrared (NIR-I) and the second near-infrared (NIR-II) biowindows. With excellent hydrophilicity and biocompatibility, the nanosheets could effectively convert the near-infrared (NIR) light into heat, showing prominent photothermal stability. The calculated photothermal conversion efficiencies reached 59.2% (under NIR-I excitation) and 69.1% (under NIR-II excitation), respectively, which are comparable to those of metallic PTAs. The NbS-PVP nanosheets had low cytotoxicity and could trigger strong photothermal treatment and cause cancer cell death upon irradiation by NIR-I or NIR-II light . Moreover, we have also demonstrated the highly efficient tissue ablation and tumor inhibition capability of NbS-PVP nanosheets . This work explores an effective PTA of two-dimensional nanomaterials in NIR-I and NIR-II biowindows and offers a reference for the design of new kinds of PTAs.
光热疗法由于其微创性、有效性和便利性，被认为是一种强大的癌症治疗手段。尽管有很大的应用前景，但由于依赖光热剂（PTA），其治疗效果受到极大限制。开发具有高光热转换性能的新型 PTA 迫在眉睫，尤其是在长波长生物窗口下进行光热治疗。在此，我们制备了一种由 NbS-PVP 纳米片组成的双生物窗口响应型 PTA，可分别在近红外一区（NIR-I）和近红外二区（NIR-II）生物窗口中使用。由于具有出色的亲水性和生物相容性，纳米片可以有效地将近红外（NIR）光转化为热能，表现出突出的光热稳定性。计算得到的光热转换效率分别达到 59.2%（在 NIR-I 激发下）和 69.1%（在 NIR-II 激发下），与金属 PTA 相当。NbS-PVP 纳米片具有低细胞毒性，在近红外光 I 或 NIR-II 照射下可以引发强烈的光热治疗并导致癌细胞死亡。此外，我们还证明了 NbS-PVP 纳米片具有高效的组织消融和肿瘤抑制能力。这项工作探索了二维纳米材料在 NIR-I 和 NIR-II 生物窗口中的有效 PTA，为新型 PTA 的设计提供了参考。
