School of Materials Science and Engineering, Nanchang University, Nanchang, Jiangxi 330031, P. R. China.
Nanoscale. 2021 Mar 18;13(10):5369-5382. doi: 10.1039/d0nr09137e.
Near-infrared (NIR) light-induced photothermal cancer therapy using nanomaterials as photothermal agents has attracted considerable research interest over the past few years. As the key factor in photothermal therapy systems, a variety of photothermal agents have been developed. However, the exploration of novel photothermal therapy nanoplatforms with high NIR absorption remains a significant challenge, especially those working in both NIR-I and NIR-II windows. In this work, Bi19S27I3 nanorods with remarkably high absorption covering the whole visible light to the entire NIR-I and NIR-II regions have been successfully prepared through a facile solvothermal approach. The as-synthesized Bi19S27I3 nanorods have a high photothermal conversion efficiency of 42.7% at 808 nm (NIR-I) and 41.5% at 1064 nm (NIR-II), making them a promising candidate for photothermal therapy. In vitro cell viability assay reveals that the Bi19S27I3 sample has good biocompatibility and exhibits significant cell-killing effect under NIR irradiation. In vivo anti-tumor experiments demonstrate that the tumor growth can be effectively inhibited by fatal hyperthermia ablation mediated by Bi19S27I3 nanorods under the irradiation of an 808 nm or 1064 nm laser. Therefore, this study should be primarily beneficial for the development of new materials for NIR photothermal therapy applications.
近红外（NIR）光诱导的光热癌症治疗使用纳米材料作为光热剂，在过去几年中引起了相当多的研究兴趣。作为光热治疗系统的关键因素，已经开发出了各种光热剂。然而，探索具有高光热吸收的新型光热治疗纳米平台仍然是一个重大挑战，特别是那些在近红外-I 和近红外-II 窗口中都能工作的平台。在这项工作中，通过简便的溶剂热方法成功制备了具有高吸收性的 Bi19S27I3 纳米棒，该纳米棒吸收范围从整个可见光到整个近红外-I 和近红外-II 区域。所合成的 Bi19S27I3 纳米棒在 808nm（近红外-I）和 1064nm（近红外-II）处的光热转换效率分别高达 42.7%和 41.5%，是一种很有前途的光热治疗候选材料。体外细胞活力测定表明，Bi19S27I3 样品具有良好的生物相容性，并在近红外照射下表现出显著的细胞杀伤效果。体内抗肿瘤实验表明，在 808nm 或 1064nm 激光照射下，Bi19S27I3 纳米棒介导的致命高热消融可有效抑制肿瘤生长。因此，这项研究应该主要有利于开发用于近红外光热治疗应用的新材料。
