• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

体内治疗探索桑叶提取物治疗大鼠 2 型糖尿病。

In vivo therapeutic exploring for Mori folium extract against type 2 diabetes mellitus in rats.

机构信息

College of Environmental and Biological Engineering, Wuhan Technology and Business University, Wuhan 430065, Hubei, P.R. China.

Department of Nutrition, The First Affiliated Hospital of Xinxiang Medical University, Weihui 453100, Henan, P.R. China.

出版信息

Biosci Rep. 2021 Dec 22;41(12). doi: 10.1042/BSR20210977.

DOI:10.1042/BSR20210977
PMID:34724560
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8661501/
Abstract

BACKGROUND

The study was aimed to investigate the potential therapeutic effect of Mori folium aqueous extracts (MFAE) on type 2 diabetes mellitus (T2DM) in vivo.

METHODS AND RESULTS

A rat model of T2DM was established with the combination of high sugar and high-fat diet (HSFD) and streptozotocin (STZ). The T2DM rats were administrated with low (2 g.kg-1) and high (5 g.kg-1) doses of MFAE for 60 consecutive days. The biochemical indices of glucose metabolism disorders, insulin resistance and oxidative stress were observed. The results indicated that MFAE significantly promoted the synthesis of hepatic glycogen, reduced the levels of fasting blood glucose and fasting blood insulin, and improved the insulin sensitivity index (ISI). MFAE administration also remarkably increased the levels of superoxide dismutase (SOD) and reduced the levels of malondialdehyde (MDA).

CONCLUSION

MFAE showed a therapeutic effect on T2DM with the bioative effect of improve glucose metabolism disorders, decrease insulin resistance, and ameliorate the antioxidative ability.

摘要

背景

本研究旨在探讨桑树叶水提物（MFAE）对 2 型糖尿病（T2DM）的潜在治疗作用。

方法和结果

采用高糖高脂饮食（HSFD）联合链脲佐菌素（STZ）建立 T2DM 大鼠模型。T2DM 大鼠给予低（2 g.kg-1）和高（5 g.kg-1）剂量的 MFAE 连续 60 天。观察葡萄糖代谢紊乱、胰岛素抵抗和氧化应激的生化指标。结果表明，MFAE 能显著促进肝糖原的合成，降低空腹血糖和空腹胰岛素水平，改善胰岛素敏感指数（ISI）。MFAE 给药还显著提高超氧化物歧化酶（SOD）的水平，降低丙二醛（MDA）的水平。

结论

MFAE 对 T2DM 具有治疗作用，其作用机制可能是改善葡萄糖代谢紊乱、降低胰岛素抵抗和改善抗氧化能力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0602/8661501/2ccdcb67cad9/bsr-41-bsr20210977-g7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0602/8661501/749927d166c2/bsr-41-bsr20210977-g1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0602/8661501/fd83d5d824de/bsr-41-bsr20210977-g2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0602/8661501/4dcd5ab055f9/bsr-41-bsr20210977-g3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0602/8661501/f08bff9d414c/bsr-41-bsr20210977-g4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0602/8661501/763b17f758fc/bsr-41-bsr20210977-g5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0602/8661501/21253885fb43/bsr-41-bsr20210977-g6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0602/8661501/2ccdcb67cad9/bsr-41-bsr20210977-g7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0602/8661501/749927d166c2/bsr-41-bsr20210977-g1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0602/8661501/fd83d5d824de/bsr-41-bsr20210977-g2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0602/8661501/4dcd5ab055f9/bsr-41-bsr20210977-g3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0602/8661501/f08bff9d414c/bsr-41-bsr20210977-g4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0602/8661501/763b17f758fc/bsr-41-bsr20210977-g5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0602/8661501/21253885fb43/bsr-41-bsr20210977-g6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0602/8661501/2ccdcb67cad9/bsr-41-bsr20210977-g7.jpg

相似文献

1
In vivo therapeutic exploring for Mori folium extract against type 2 diabetes mellitus in rats.体内治疗探索桑叶提取物治疗大鼠 2 型糖尿病。
Biosci Rep. 2021 Dec 22;41(12). doi: 10.1042/BSR20210977.
2
Dacryodes edulis (G. Don) H.J. Lam modulates glucose metabolism, cholinergic activities and Nrf2 expression, while suppressing oxidative stress and dyslipidemia in diabetic rats.使君子调节葡萄糖代谢、胆碱能活动和 Nrf2 表达，同时抑制糖尿病大鼠的氧化应激和血脂异常。
J Ethnopharmacol. 2020 Jun 12;255:112744. doi: 10.1016/j.jep.2020.112744. Epub 2020 Mar 9.
3
Sanbai Melon Seed Oil Exerts Its Protective Effects in a Diabetes Mellitus Model via the Akt/GSK-3/Nrf2 Pathway.三白瓜籽油通过 Akt/GSK-3/Nrf2 通路发挥其在糖尿病模型中的保护作用。
J Diabetes Res. 2019 Sep 12;2019:5734723. doi: 10.1155/2019/5734723. eCollection 2019.
4
Epigallocatechin-3-gallate ameliorates glucolipid metabolism and oxidative stress in type 2 diabetic rats.没食子儿茶素没食子酸酯改善 2 型糖尿病大鼠的糖脂代谢和氧化应激。
Diab Vasc Dis Res. 2020 Nov-Dec;17(6):1479164120966998. doi: 10.1177/1479164120966998.
5
Antidiabetogenic action of Morus rubra L. leaf extract in streptozotocin-induced diabetic rats.桑叶提取物对链脲佐菌素诱导糖尿病大鼠的抗糖尿病作用。
J Pharm Pharmacol. 2010 Feb;62(2):247-55. doi: 10.1211.jpp/62.02.0013.
6
[Therapeutic effects of gegen qinlian decoction and its mechanism of action on type 2 diabetic rats].葛根芩连汤对2型糖尿病大鼠的治疗作用及其作用机制
Yao Xue Xue Bao. 2013 Sep;48(9):1415-21.
7
Protective effect of acorn (Quercus liaotungensis Koidz) on streptozotocin-damaged MIN6 cells and type 2 diabetic rats via p38 MAPK/Nrf2/HO-1 pathway.橡实（辽东栎）通过 p38MAPK/Nrf2/HO-1 通路对链脲佐菌素损伤的 MIN6 细胞及 2 型糖尿病大鼠的保护作用。
J Ethnopharmacol. 2021 Feb 10;266:113444. doi: 10.1016/j.jep.2020.113444. Epub 2020 Oct 4.
8
Protective effects of Ficus carica leaves on glucose and lipids levels, carbohydrate metabolism enzymes and β-cells in type 2 diabetic rats.无花果叶对2型糖尿病大鼠血糖、血脂水平、碳水化合物代谢酶及β细胞的保护作用
Pharm Biol. 2017 Dec;55(1):1074-1081. doi: 10.1080/13880209.2017.1279671.
9
The effect of Liuwei Dihuang decoction on PI3K/Akt signaling pathway in liver of type 2 diabetes mellitus (T2DM) rats with insulin resistance.六味地黄汤对胰岛素抵抗的2型糖尿病（T2DM）大鼠肝脏PI3K/Akt信号通路的影响
J Ethnopharmacol. 2016 Nov 4;192:382-389. doi: 10.1016/j.jep.2016.07.024. Epub 2016 Jul 9.
10
Flavonoids extracted from mulberry (Morus alba L.) leaf improve skeletal muscle mitochondrial function by activating AMPK in type 2 diabetes.桑叶（Morus alba L.）中提取的类黄酮通过激活 2 型糖尿病中的 AMPK 来改善骨骼肌线粒体功能。
J Ethnopharmacol. 2020 Feb 10;248:112326. doi: 10.1016/j.jep.2019.112326. Epub 2019 Oct 19.

引用本文的文献

1
Metabolomics Analysis of the Mechanism of Yuquan Capsules in the Treatment of T2DM Rats Using UPLC/MS.基于超高效液相色谱/质谱联用技术的玉泉胶囊治疗2型糖尿病大鼠机制的代谢组学分析
Diabetes Metab Syndr Obes. 2025 Mar 27;18:905-916. doi: 10.2147/DMSO.S512089. eCollection 2025.
2
Lutein-Rich Beverage Alleviates Visual Fatigue in the Hyperglycemia Model of Sprague-Dawley Rats.富含叶黄素的饮料可缓解Sprague-Dawley大鼠高血糖模型中的视觉疲劳。
Metabolites. 2023 Oct 27;13(11):1110. doi: 10.3390/metabo13111110.
3
Fufang Fanshiliu Decoction Revealed the Antidiabetic Effect through Modulating Inflammatory Response and Gut Microbiota Composition.

本文引用的文献

1
To the Editor: Metformin for type 2 diabetes.致编辑：二甲双胍用于2型糖尿病。
Cleve Clin J Med. 2019 Apr;86(4):237. doi: 10.3949/ccjm.86c.04003.
2
Association of Hypoglycemia With Subsequent Dementia in Older Patients With Type 2 Diabetes Mellitus.2型糖尿病老年患者低血糖与随后发生痴呆的关联。
J Gerontol A Biol Sci Med Sci. 2019 Apr 23;74(5):750. doi: 10.1093/gerona/glz053.
3
High-fat diet and streptozotocin in the induction of type 2 diabetes mellitus: a new proposal.高脂肪饮食与链脲佐菌素诱导2型糖尿病：一项新提议。
复方番石榴流浸膏汤通过调节炎症反应和肠道微生物群组成发挥抗糖尿病作用。
Evid Based Complement Alternat Med. 2022 Oct 10;2022:3255401. doi: 10.1155/2022/3255401. eCollection 2022.
4
Isolation of Chalcomoracin as a Potential α-Glycosidase Inhibitor from Mulberry Leaves and Its Binding Mechanism.从桑叶中分离出作为潜在α-糖苷酶抑制剂的桑辛素及其结合机制。
Molecules. 2022 Sep 6;27(18):5742. doi: 10.3390/molecules27185742.
5
Phytochemistry, Pharmacology and Quality Control of Xiasangju: A Traditional Chinese Medicine Formula.夏桑菊：一种中药配方的植物化学、药理学及质量控制
Front Pharmacol. 2022 Jun 23;13:930813. doi: 10.3389/fphar.2022.930813. eCollection 2022.
An Acad Bras Cienc. 2019 Mar 21;91(1):e20180314. doi: 10.1590/0001-3765201920180314.
4
Reduced Intracerebral Hemorrhage and Perihematomal Edema Volumes in Diabetics on Sulfonylureas.磺酰脲类药物可减少糖尿病患者的脑出血和血肿周围水肿体积。
Stroke. 2019 Apr;50(4):995-998. doi: 10.1161/STROKEAHA.118.022301.
5
Potential Nexus of Non-alcoholic Fatty Liver Disease and Type 2 Diabetes Mellitus: Insulin Resistance Between Hepatic and Peripheral Tissues.非酒精性脂肪性肝病与2型糖尿病之间的潜在联系：肝脏与外周组织之间的胰岛素抵抗
Front Pharmacol. 2019 Jan 14;9:1566. doi: 10.3389/fphar.2018.01566. eCollection 2018.
6
Type 2 diabetes mellitus increases the risk of hepatocellular carcinoma in subjects with chronic hepatitis B virus infection: a meta-analysis and systematic review.2型糖尿病增加慢性乙型肝炎病毒感染患者肝细胞癌的风险：一项荟萃分析和系统评价。
Cancer Manag Res. 2019 Jan 14;11:705-713. doi: 10.2147/CMAR.S188238. eCollection 2019.
7
Efficacy and Safety of Premixed Human Insulin Combined with Sulfonylureas in Type 2 Diabetic Patients Previously Poorly Controlled with Insulin.预混人胰岛素联合磺脲类药物治疗既往胰岛素控制不佳的2型糖尿病患者的疗效与安全性
Diabetes Ther. 2019 Apr;10(2):463-471. doi: 10.1007/s13300-019-0564-z. Epub 2019 Jan 18.
8
Rodent models of diet-induced type 2 diabetes mellitus: A literature review and selection guide.饮食诱导型2型糖尿病的啮齿动物模型：文献综述与选择指南
Diabetes Metab Syndr. 2019 Jan-Feb;13(1):195-200. doi: 10.1016/j.dsx.2018.07.020. Epub 2018 Jul 31.
9
Risk of Dementia in Older Patients with Type 2 Diabetes on Dipeptidyl-Peptidase IV Inhibitors Versus Sulfonylureas: A Real-World Population-Based Cohort Study.老年 2 型糖尿病患者使用二肽基肽酶 -4 抑制剂与磺脲类药物相比患痴呆症的风险：一项基于真实世界人群的队列研究
J Clin Med. 2018 Dec 28;8(1):28. doi: 10.3390/jcm8010028.
10
[Pharmacokinetics of Mori Folium flavones and alkaloids in normal and diabetic rats].[桑叶黄酮和生物碱在正常及糖尿病大鼠体内的药代动力学]
Zhongguo Zhong Yao Za Zhi. 2017 Nov;42(21):4218-4225. doi: 10.19540/j.cnki.cjcmm.20170901.008.