Imaizumi T, Mitsuhashi Y, Katabira Y
Ann Dermatol Venereol. 1986;113(5):427-34.
The present study deals with the results of topical treatment of psoriasis with ACNU (nimustine hydrochloride), a water-soluble derivative of nitrosourea developed in Japan. Solutions at concentrations of 0.1 p. 100, 0.2 p. 100 and 0.4 p. 100 were obtained by dissolving ACNU in water and alcohol. An 0.4 p. 100 ointment was prepared by mixing ACNU with polyethylene glycol. Seventeen patients (12 male and 5 female), ranging in age from 19 to 68 years, were treated. Improvement of the skin lesions was observed in all 10 patients treated with the solution and in 6 of the 7 patients treated with the ointment. Clinical and histological pictures of the 4 main cases are shown with photographs. Compared with other treatments, the ACNU solution and ointment have the same effect as corticosteroid ointments of moderate strength or Goeckerman therapy. Side-effects included papules, redness, pigmentation and irritation. ACNU has been used for the treatment of mycosis fungoides, but we were the first to use this drug in psoriasis. This treatment has some side-effects, but they are less severe than those of other anti-cancer drugs. ACNU is relatively expensive and unsuitable for long term use. Thus, topical applications of ACNU may be of some value in cases where conventional treatments have failed.
本研究探讨了用ACNU（盐酸尼莫司汀）对银屑病进行局部治疗的结果，ACNU是日本研制的一种亚硝基脲的水溶性衍生物。将ACNU溶于水和酒精中，分别得到浓度为0.1%、0.2%和0.4%的溶液。将ACNU与聚乙二醇混合制备出0.4%的软膏。对17例患者（12例男性和5例女性，年龄在19至68岁之间）进行了治疗。在接受溶液治疗的所有10例患者以及接受软膏治疗的7例患者中的6例中，观察到皮肤损害有所改善。展示了4例主要病例的临床和组织学图片及照片。与其他治疗方法相比，ACNU溶液和软膏的效果与中等强度的皮质类固醇软膏或Goeckerman疗法相同。副作用包括丘疹、发红、色素沉着和刺激。ACNU已用于蕈样肉芽肿的治疗，但我们是首次将该药物用于银屑病的治疗。这种治疗有一些副作用，但比其他抗癌药物的副作用要轻。ACNU相对昂贵，不适合长期使用。因此，在传统治疗失败的情况下，ACNU的局部应用可能具有一定价值。
