Jimbow K, Horikoshi T, Kamimura M
Gan To Kagaku Ryoho. 1982 Jul;9(7):1231-6.
The effects of topical chemotherapy of 1-(4-amino-2-methyl-5-pyrimidinyl) methyl-3-(2-chloroethyl)-3-nitrosourea hydrochloride (ACNU) on the lesions of mycosis fungoides were evaluated in 7 patients, ranging in age from 44 to 79 years old. Either 0.2% or 0.4% concentration of ACNU, in ointment and ethanol was used. 0.4% ACNU ethanol solution was effective in bringing the plaque lesions under satisfactory control with a complete clearance. ACNU was painted two to three times a week with a maximum dose of 50mg. Irritation and erosion of the applied areas were the major side effects, which were however, controlled by topical steroid ointment. No serious side effects of marrow and liver function were found even when ACNU was applied as long as 40 months (total ACNU dose: 16 gm). Histologically the cleared lesions revealed the thinning of epidermis, almost complete loss of lymphocytic infiltrates and fibrosis of dermis which was density infiltrated by lymphocytes prior to the ACNU therapy. Thus, topical chemotherapy of ACNU appears to be encouraged for modifying the plaque lesions of mycosis fungoides.
对7例年龄在44至79岁之间的蕈样肉芽肿患者，评估了1-(4-氨基-2-甲基-5-嘧啶基)甲基-3-(2-氯乙基)-3-亚硝基脲盐酸盐（ACNU）局部化疗对其皮损的疗效。使用了0.2%或0.4%浓度的ACNU软膏及乙醇溶液。0.4%的ACNU乙醇溶液能有效控制斑块状皮损，使其完全消退。每周涂抹ACNU两至三次，最大剂量为50mg。用药部位的刺激和糜烂是主要副作用，但可通过外用类固醇软膏控制。即使ACNU应用长达40个月（ACNU总剂量：16g），也未发现骨髓和肝功能的严重副作用。组织学上，消退的皮损显示表皮变薄，淋巴细胞浸润几乎完全消失，真皮纤维化，而在ACNU治疗前真皮有密集的淋巴细胞浸润。因此，ACNU局部化疗似乎可用于改善蕈样肉芽肿的斑块状皮损。
