Guerrero-Romero Fernando, Morales-Gurrola Gerardo, Preza-Rodríguez Lucía, Gómez-Barrientos Alejandra, Olivas-Martínez Ana I, Simental-Mendía Luis E
Unidad de Investigación Biomédica, Instituto Mexicano del Seguro Social, Durango, Mexico.
Facultad de Medicina y Nutrición, Universidad Juárez del Estado de Durango, Durango, Mexico.
J Investig Med. 2022 Mar;70(3):800-804. doi: 10.1136/jim-2021-001841. Epub 2021 Nov 1.
Although magnesium intake is inversely associated with the risk of metabolic abnormalities, whether magnesium intake plays a role on metabolically healthy obese (MHO) phenotype has not been explored. Therefore, the purpose of this study was to determine whether the magnesium intake is associated with the MHO phenotype. Apparently, healthy women and men aged 20-65 years with obesity were enrolled in a cross-sectional study. Subjects were allocated into MHO (n=124) and metabolically unhealthy obese (MUO) (n=123) groups. MHO phenotype was defined by abdominal obesity (waist circumference ≥90 cm in men and ≥80 cm in women) and none, or not more than one of the following risk factors: triglyceride levels ≥150 mg/dL; high-density lipoprotein cholesterol (HDL-C) levels <40 mg/dL in men and <50 mg/dL in women; fasting glucose ≥100 mg/dL; and systolic blood pressure ≥130 mm Hg and/or diastolic blood pressure ≥85 mm Hg. The MUO individuals were characterized by abdominal obesity and the presence of two or more of the aforementioned criteria. The proportion of individuals with high blood pressure (40.7% vs 5.6%, p<0.001), hyperglycemia (69.1% vs 16.9%, p<0.001), hypertriglyceridemia (84.6% vs 36.3%, p<0.001), and low HDL-C (51.2% vs 12.9%, p<0.001) was significantly higher in the MUO individuals as compared with individuals in the MHO group. The logistic regression analysis adjusted by sex and age showed that dietary magnesium intake is significantly associated with the MHO phenotype (OR=1.17; 95% CI 1.07 to 1.25, p=0.005). Our results show that magnesium intake is significantly associated with the MHO phenotype.
尽管镁摄入量与代谢异常风险呈负相关，但镁摄入量是否对代谢健康的肥胖（MHO）表型起作用尚未得到研究。因此，本研究的目的是确定镁摄入量是否与MHO表型相关。显然，20 - 65岁患有肥胖症的健康女性和男性被纳入一项横断面研究。受试者被分为MHO组（n = 124）和代谢不健康的肥胖（MUO）组（n = 123）。MHO表型的定义为腹部肥胖（男性腰围≥90厘米，女性腰围≥80厘米）且无以下危险因素，或不超过一项以下危险因素：甘油三酯水平≥150毫克/分升；男性高密度脂蛋白胆固醇（HDL-C）水平<40毫克/分升，女性<50毫克/分升；空腹血糖≥100毫克/分升；收缩压≥130毫米汞柱和/或舒张压≥85毫米汞柱。MUO个体的特征为腹部肥胖且存在上述两项或更多标准。与MHO组个体相比，MUO个体中高血压（40.7%对5.6%，p<0.001）、高血糖（69.1%对16.9%，p<0.001）、高甘油三酯血症（84.6%对36.3%，p<0.001）和低HDL-C（51.2%对12.9%，p<0.001）的个体比例显著更高。经性别和年龄调整的逻辑回归分析表明，膳食镁摄入量与MHO表型显著相关（OR = 1.17；95%置信区间1.07至1.25，p = 0.005）。我们的结果表明，镁摄入量与MHO表型显著相关。
