Department of Pharmacy, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 430030 Wuhan, China.
Hubei Province Clinical Research Center for Precision Medicine for Critical Illness, 430030 Wuhan, China.
Dis Markers. 2021 Oct 22;2021:3440714. doi: 10.1155/2021/3440714. eCollection 2021.
It has been observed that COVID-19 may cause myocardial damage, but there are few detailed reports on myocardial enzyme abnormalities.
In this retrospective study, we analyzed data from 157 consecutive laboratory-confirmed and hospitalized COVID-19 patients from Wuhan. We collected information on demographic and clinical characteristics, laboratory findings, and clinical outcomes. Logistic regression analysis was used to explore the risk factors associated with the severity of COVID-19. The association between myocardial enzyme abnormalities and the mortality was also investigated.
The mortality in abnormal myocardial enzyme group was obviously higher than the normal group ( < 0.001). The majority of patients ( = 72, 97.3%) with normal cardiac enzyme group were of the common novel coronavirus pneumonia (NCP) type, whereas half of the patients with cardiac enzyme abnormalities ( = 40, 48.2%) developed critical and severe NCP type. The multivariable logistic regression analysis indicated that COVID-19 patients with increasing age ( = 0.035), higher levels of CRP ( = 0.038), and TNI ( = 0.036) were associated with increased death than other patients.
Myocardial enzyme abnormality and myocardial injury were associated with the severity and fatal outcomes of COVID-19. Clinicians should pay attention to the markers of myocardial injury in COVID-19 patients, especially those with older age, comorbidities, and inflammation.
有观察表明，COVID-19 可能导致心肌损伤，但关于心肌酶异常的详细报告较少。
在这项回顾性研究中，我们分析了来自武汉的 157 例连续实验室确诊和住院的 COVID-19 患者的数据。我们收集了人口统计学和临床特征、实验室结果和临床结局的信息。使用逻辑回归分析探讨与 COVID-19 严重程度相关的危险因素。还研究了心肌酶异常与死亡率之间的关系。
心肌酶异常组的死亡率明显高于正常组（<0.001）。正常心肌酶组的大多数患者（n=72，97.3%）为普通新型冠状病毒肺炎（NCP）型，而心肌酶异常组中有一半患者（n=40，48.2%）发展为危重症 NCP 型。多变量逻辑回归分析表明，与其他患者相比，COVID-19 患者年龄增加（=0.035）、CRP 水平升高（=0.038）和 TNI 水平升高（=0.036）与死亡风险增加相关。
心肌酶异常和心肌损伤与 COVID-19 的严重程度和致死结局相关。临床医生应注意 COVID-19 患者心肌损伤的标志物，尤其是那些年龄较大、合并症和炎症的患者。
