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通过陈-西蒙斯电流产生的DNA突变。

DNA Mutations via Chern-Simons Currents.

作者信息

Bajardi Francesco, Altucci Lucia, Benedetti Rosaria, Capozziello Salvatore, Sorbo Maria Rosaria Del, Franci Gianluigi, Altucci Carlo

机构信息

Dipartimento di Fisica "Ettore Pancini", Università degli Studi di Napoli"Federico II", Compl. Univ. di Monte S. Angelo, Edificio G, Via Cinthia, 80126 Napoli, Italy.

INFN Sezione di Napoli, Compl. Univ. di Monte S. Angelo, Edificio G, Via Cinthia, 80126 Napoli, Italy.

出版信息

Eur Phys J Plus. 2021;136(10):1080. doi: 10.1140/epjp/s13360-021-01960-5. Epub 2021 Oct 28.

DOI:10.1140/epjp/s13360-021-01960-5
PMID:34725629
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8551353/
Abstract

We test the validity of a possible schematization of DNA structure and dynamics based on the Chern-Simons theory, that is a topological field theory mostly considered in the context of effective gravity theories. By means of the expectation value of the Wilson Loop, derived from this analogue gravity approach, we find the point-like curvature of genomic strings in KRAS human gene and COVID-19 sequences, correlating this curvature with the genetic mutations. The point-like curvature profile, obtained by means of the Chern-Simons currents, can be used to infer the position of the given mutations within the genetic string. Generally, mutations take place in the highest Chern-Simons current gradient locations and subsequent mutated sequences appear to have a smoother curvature than the initial ones, in agreement with a free energy minimization argument.

摘要

我们基于陈 - 西蒙斯理论检验了一种可能的DNA结构与动力学图式的有效性，陈 - 西蒙斯理论是一种主要在有效引力理论背景下被考虑的拓扑场论。通过从这种类比引力方法导出的威尔逊圈的期望值，我们发现了KRAS人类基因和新冠病毒序列中基因组链的点状曲率，并将这种曲率与基因突变相关联。通过陈 - 西蒙斯流获得的点状曲率轮廓可用于推断给定突变在基因链中的位置。一般来说，突变发生在陈 - 西蒙斯流梯度最高的位置，并且随后的突变序列似乎比初始序列具有更平滑的曲率，这与自由能最小化的观点一致。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/756d/8551353/dc9320026b4b/13360_2021_1960_Fig17_HTML.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/756d/8551353/dc9320026b4b/13360_2021_1960_Fig17_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/756d/8551353/04751a282e70/13360_2021_1960_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/756d/8551353/09d5ad9e625f/13360_2021_1960_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/756d/8551353/507c1255ae6a/13360_2021_1960_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/756d/8551353/257338c99340/13360_2021_1960_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/756d/8551353/9f637d184530/13360_2021_1960_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/756d/8551353/2d635f09992a/13360_2021_1960_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/756d/8551353/e6d2ba2f68b0/13360_2021_1960_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/756d/8551353/e94b0e44277f/13360_2021_1960_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/756d/8551353/9d6ede39c588/13360_2021_1960_Fig9_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/756d/8551353/e2b40fe71e46/13360_2021_1960_Fig10_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/756d/8551353/926f66a7a652/13360_2021_1960_Fig11_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/756d/8551353/f6e7fa7afb26/13360_2021_1960_Fig12_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/756d/8551353/54914861c8b2/13360_2021_1960_Fig13_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/756d/8551353/f6a7192193ae/13360_2021_1960_Fig14_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/756d/8551353/f6a7192193ae/13360_2021_1960_Fig15_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/756d/8551353/9bfcd980c2c6/13360_2021_1960_Fig16_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/756d/8551353/dc9320026b4b/13360_2021_1960_Fig17_HTML.jpg

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