BT-Academy, Center for Special Care in Dentistry Amsterdam, Amsterdam, The Netherlands.
Private Practice, Zoetermeer, The Netherlands.
Gerodontology. 2022 Dec;39(4):330-338. doi: 10.1111/ger.12590. Epub 2021 Nov 2.
Oral bisphosphonates are widely used in the treatment of bone resorptive diseases. There is an evidence that oral bisphosphonates can exert adverse effects on the oral mucosa independently of their effects on the jaw bones.
To systematically map the literature on adverse effects of oral bisphosphonates on the oral mucosa of adults with bone resorptive diseases.
Scoping review of the literature, including different study designs.
Systematic searches of the PubMed, LILACS, Google Scholar and EMBASE databases were conducted. Two independent reviewers screened titles and abstracts according to predetermined criteria.
The search retrieved 26 unique articles, comprising 22 case reports, one case series and three reviews describing a total of 56 cases of oral adverse events related to oral bisphosphonates. 88% of the reported cases were female suffering from comorbidities other than metabolic bone diseases. The improper use of the oral bisphosphonate was the most suspected cause of the adverse effect on the oral mucosa. Its management mainly involved withdrawal of the medication.
Adverse effects on the oral mucosa can develop from using oral bisphosphonates. Standardised registration of these adverse effects in university clinics and private practises could provide additional information about their occurrence and severity.
口服双膦酸盐被广泛用于治疗骨质吸收性疾病。有证据表明，口服双膦酸盐除了对颌骨有影响外，还会对口腔黏膜产生不良影响。
系统地绘制关于口服双膦酸盐对患有骨质吸收性疾病的成年人的口腔黏膜的不良影响的文献。
文献范围综述，包括不同的研究设计。
对 PubMed、LILACS、Google Scholar 和 EMBASE 数据库进行了系统检索。两名独立的审查员根据预先确定的标准筛选标题和摘要。
检索到 26 篇独特的文章，包括 22 篇病例报告、1 篇病例系列和 3 篇综述，总共描述了 56 例与口服双膦酸盐相关的口腔不良事件。报告的病例中 88%为患有代谢性骨病以外的合并症的女性。口腔双膦酸盐的不当使用是口腔黏膜不良事件最可疑的原因。其管理主要涉及停药。
使用口服双膦酸盐可能会导致口腔黏膜的不良反应。在大学诊所和私人诊所对这些不良反应进行标准化登记，可以提供有关其发生和严重程度的更多信息。
