双膦酸盐对舌黏膜的影响：一项实验性电子显微镜研究。
Bisphosphonate's Effect on Tongue Mucosa: An Experimental Electron Microscopy Study.
作者信息
Papamitsou Theodora, Morsi-Yeroyannis Antonios, Papanastasiou Anastasios, Bakalopoulos Nikolaos, Dietrich Eva-Maria, Karachrysafi Sofia, Toskas Alexandros, Mareti Evangelia, Morsi-Yeroyanni Anastasia, Sioga Antonia
机构信息
Laboratory of Histology-Embryology, Faculty of Medicine, School of Health Sciences, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece.
Faculty of Medicine, School of Health Sciences, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece.
出版信息
Medicina (Kaunas). 2020 Jan 24;56(2):51. doi: 10.3390/medicina56020051.
BACKGROUND AND OBJECTIVES
Bisphosphonates (BPs) are selective inhibitors of osteoclasts, used for the treatment of bone disorders. The objective of this study is to investigate the possible effects of BPs on the tongue's mucosa.
MATERIALS AND METHODS
Specimens of the tongue of 20 female 12-month old Wistar rats were taken. Ten were used as control group, while in the remaining alendronate (Fosamax, Merck) was administered per os from 13 weeks. Observation of the harvested samples was made by Transmission Electron Microscopy (TEM).
RESULTS
In the experimental group, focal alterations were observed to various extent in all specimens. The basement membrane was intact. Furthermore, an increase at the intercellular space was observed, predominantly at the middle layer, and the desmosomes were disorganized. In the lamina propria focal edema was observed.
CONCLUSIONS
Investigation on the effect of BPs on the tongue's mucosa through TEM hasn't been documented in the past. According to our results, BPs seem to cause mild mucosal lesions on the tongue.
背景与目的
双膦酸盐（BPs）是破骨细胞的选择性抑制剂，用于治疗骨疾病。本研究的目的是调查双膦酸盐对舌黏膜可能产生的影响。
材料与方法
取20只12月龄雌性Wistar大鼠的舌标本。10只作为对照组，其余10只从第13周开始口服阿仑膦酸钠（福善美，默克公司）。通过透射电子显微镜（TEM）对采集的样本进行观察。
结果
在实验组中，所有标本均观察到不同程度的局灶性改变。基底膜完整。此外，观察到细胞间隙增加，主要在中层，且桥粒紊乱。在固有层观察到局灶性水肿。
结论
过去尚未有通过透射电子显微镜研究双膦酸盐对舌黏膜影响的文献记载。根据我们的结果，双膦酸盐似乎会导致舌部出现轻度黏膜病变。
Zotero 插件