Takeuchi Masahiro, Katsuki Takefumi, Yoshida Kumiko, Onoda Masahiko, Iwamura Michinori, Inokuchi Toshihiro, Furutani Akira, Katoh Tomoe, Kawano Kazuaki, Hirata Keiji
Department of Surgery, Yamaguchi Rosai Hospital, Yamaguchi, Japan.
Department of Surgery 1, School of Medicine, University of Occupational and Environmental Health, Fukuoka, Japan.
J Breast Cancer. 2021 Oct;24(5):481-490. doi: 10.4048/jbc.2021.24.e46.
Locally advanced breast cancer (tumor > 5 cm, widespread infiltration of the skin and muscle, or metastases to lymph nodes) is difficult to resect by surgery, and even when it is resectable, there is a high probability of local recurrence and distant metastasis. Therefore, systemic therapy should be administered first. However, as cutaneous infiltration progresses, the patient's quality of life is impaired by pain, bleeding, presence of exudates, and a foul-smelling odor. Treatment with Mohs paste with systemic therapy can control symptoms associated with skin infiltration and can also be expected to decrease tumor volume. Herein, we report a case in which a tumor was resected following Mohs paste and systemic chemotherapy administration, and the skin defect was reconstructed with a latissimus dorsi myocutaneous flap. We also review the literature for previously reported cases of breast cancer involving Mohs paste.
局部晚期乳腺癌（肿瘤直径>5 cm、皮肤和肌肉广泛浸润或有淋巴结转移）难以通过手术切除，即使可切除，局部复发和远处转移的概率也很高。因此，应首先进行全身治疗。然而，随着皮肤浸润的进展，患者的生活质量会受到疼痛、出血、有渗出物以及恶臭的影响。莫氏糊剂联合全身治疗可以控制与皮肤浸润相关的症状，还有望缩小肿瘤体积。在此，我们报告一例在使用莫氏糊剂并进行全身化疗后切除肿瘤，并用背阔肌肌皮瓣修复皮肤缺损的病例。我们还回顾了文献中先前报道的涉及莫氏糊剂的乳腺癌病例。
