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类风湿关节炎患者体力活动随机对照试验中参与者和退出者的特征:一项基于回顾性登记的横断面研究。

Characteristics of participants and decliners from a randomized controlled trial on physical activity in patients with rheumatoid arthritis: a retrospective register-based cross-sectional study.

机构信息

Copenhagen Center for Arthritis Research, Center for Rheumatology and Spine Diseases, Centre for Head and Orthopaedics, Rigshospitalet, Copenhagen, Denmark.

Center for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark.

出版信息

Scand J Rheumatol. 2023 Jan;52(1):17-24. doi: 10.1080/03009742.2021.1975394. Epub 2021 Nov 2.

DOI:10.1080/03009742.2021.1975394
PMID:34726121
Abstract

OBJECTIVE

A randomized controlled trial [Joint Resources - Sedentary Behaviour (JR-SB) intervention] aimed to reduce sedentary behaviour and increase light-intensity physical activity in patients with rheumatoid arthritis (RA) through motivational counselling and text messages. Since a large proportion of invited patients declined to participate, this study aims to compare sociodemographic, clinical, and lifestyle factors between included patients and patients declining to participate (non-participants) in the JR-SB study and to investigate which characteristics were associated with participation.

METHOD

A register-based cross-sectional study was conducted. All patients invited to participate in the JR-SB study were identified in the DANBIO registry, from which patients' clinical and lifestyle data were also retrieved. Data on sociodemography and comorbidity were extracted from national registers. Differences between participants and non-participants were determined by an independent t-test or a chi-squared test. Logistic regression analyses adjusted for various confounders tested the association of patient characteristics with the likelihood of participation in the JR-SB study.

RESULTS

A total of 467 (58%) declined participation in the JR-SB study. Non-participants were older and less educated, more were smokers, fewer performed regular physical activity, and more had comorbidity compared to participants. Regression analyses showed that a higher educational level and absence of comorbidity in particular were associated with participation in the JR-SB study.

CONCLUSION

Patients with RA who are less educated and with certain types of comorbidity are less motivated to participate in a physical activity intervention. The findings may inform the recruitment process and implementation of physical activity interventions in rheumatology clinical practice.

摘要

目的

一项随机对照试验(联合资源-久坐行为干预[JR-SB])旨在通过动机咨询和短信减少类风湿关节炎(RA)患者的久坐行为并增加低强度体力活动。由于很大一部分受邀患者拒绝参与,本研究旨在比较纳入患者和拒绝参与 JR-SB 研究的患者(非参与者)的社会人口统计学、临床和生活方式因素,并调查哪些特征与参与相关。

方法

进行了一项基于登记的横断面研究。从 DANBIO 登记处确定了所有受邀参与 JR-SB 研究的患者,并从中检索了患者的临床和生活方式数据。社会人口统计学和合并症的数据从国家登记处提取。参与者和非参与者之间的差异通过独立 t 检验或卡方检验确定。通过逻辑回归分析调整了各种混杂因素,测试了患者特征与参与 JR-SB 研究的可能性之间的关联。

结果

共有 467 名(58%)患者拒绝参与 JR-SB 研究。与参与者相比,非参与者年龄较大,受教育程度较低,更多人吸烟,定期进行体力活动的人较少,合并症更多。回归分析显示,较高的教育水平和没有特定类型的合并症与参与 JR-SB 研究有关。

结论

受教育程度较低和有某些类型合并症的 RA 患者参与体力活动干预的积极性较低。这些发现可能为招募过程和在风湿病临床实践中实施体力活动干预提供信息。

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