乙状结肠肿瘤细胞中的16号染色体（p13q22）倒位。

Inversion (16)(p13q22) in tumor cells of sigmoid colon.

作者信息

Shabtai F, Sternberg A, Klar D, Reiss R, Halbrecht I

出版信息

Cancer Genet Cytogenet. 1987 Jul;27(1):171-5. doi: 10.1016/0165-4608(87)90272-x.

Abstract

We report on the cytogenetic findings in direct preparations of two tumors of the sigmoid colon. Respectively, they had a near-triploid and a near-tetraploid constitution and relative numerical and other inconstant chromosomal imbalances. The only constant chromosomal structural anomaly apparently was inversion of chromosome #16, inv(16)(p13q22), which was found in all the cells examined. This rearrangement has been found to be associated with a type of acute myelomonocytic leukemia type M4. We suggest that an etiologic clastogenic (and oncogenic) agent responsible for this rearrangement may eventually be the cause of various kinds of malignancy.

摘要

我们报告了乙状结肠的两种肿瘤直接制片的细胞遗传学研究结果。它们分别具有近三倍体和近四倍体核型，以及相对的数值和其他不稳定的染色体失衡。唯一恒定的染色体结构异常显然是16号染色体倒位，inv(16)(p13q22)，在所检查的所有细胞中均发现。这种重排已被发现与一种M4型急性粒单核细胞白血病相关。我们认为，导致这种重排的一种致断裂（和致癌）病因学因素最终可能是各种恶性肿瘤的病因。