慢性粒单核细胞白血病中16号染色体的臂间倒位与嗜酸性粒细胞增多

Pericentric inversion of chromosome 16 and eosinophilia in chronic myelomonocytic leukemia.

作者信息

Miyamoto T, Akashi K, Hayashi S, Oogami A, Okamura T, Iwasaki H, Murakawa M, Harada M, Niho Y

机构信息

Department of Hematology, Harasanshin General Hospital, Fukuoka, Japan.

出版信息

Cancer Genet Cytogenet. 1997 Apr;94(2):99-102. doi: 10.1016/s0165-4608(96)00207-5.

DOI:10.1016/s0165-4608(96)00207-5

PMID:9109936

Abstract

We report a case of myelodysplastic syndrome with bone marrow eosinophilia and the chromosomal abnormality, inv(16)(p13q22). Hematologic findings including monocytosis and trilineage myelodysplasia were consistent with chronic myelomonocytic leukemia, and numerous abnormal eosinophils were present in the bone marrow. Chromosomal analysis of all metaphase cells from peripheral blood and bone marrow revealed in(16)(p13q22), which is well known characteristic of acute myelomonocytic leukemia with eosinophilia (M4Eo). Both monocytes and eosinophils in this case may be derived from common leukemic progenitors affected by inv(16)(p13q22).

摘要

我们报告一例伴有骨髓嗜酸性粒细胞增多和染色体异常inv(16)(p13q22)的骨髓增生异常综合征。包括单核细胞增多和三系骨髓发育异常在内的血液学表现与慢性粒单核细胞白血病相符，骨髓中存在大量异常嗜酸性粒细胞。对外周血和骨髓所有中期细胞进行染色体分析，发现inv(16)(p13q22)，这是伴有嗜酸性粒细胞增多的急性粒单核细胞白血病（M4Eo）的典型特征。该病例中的单核细胞和嗜酸性粒细胞可能均来源于受inv(16)(p13q22)影响的共同白血病祖细胞。