利匹司特滴眼液改善巨细胞病毒性角膜内皮炎合并大疱性角膜病变：一例报告。
Ripasudil Eyedrops Ameliorated Bullous Keratopathy Complicated with Cytomegalovirus Corneal Endotheliitis: A Case Report.
机构信息
Department of Ophthalmology, Tohoku University Graduate School of Medicine, Sendai, Japan.
Department of Retinal Disease Control, Tohoku University Graduate School of Medicine, Sendai, Japan.
出版信息
Ocul Immunol Inflamm. 2023 Jan;31(1):207-210. doi: 10.1080/09273948.2021.1988114. Epub 2021 Nov 2.
PURPOSE
We describe a case of bullous keratopathy complicated with cytomegalovirus (CMV) corneal endotheliitis that was successfully treated with ripasudil eye drops.
METHODS
A retrospective case report.
RESULTS
A 65-year-old female patient diagnosed with CMV-associated anterior uveitis in the right eye was referred to us when anterior uveitis recurred with bullous keratopathy. Initial best-corrected visual acuity (BCVA) was 0.4 (decimal visual acuity). Her condition did not improve with anti-CMV treatment, and BCVA decreased to 0.07. At this point, intraocular pressure (IOP) was 20 mmHg, and ripasudil eye drops were started for IOP control. After 1 month, not only had IOP decreased to 14 mm Hg but the condition of the corneal edema had also improved. The central corneal thickness decreased to a normal level, and the BCVA recovered to 0.8.
CONCLUSION
Ripasudil eye drops not only lower IOP in patients with CMV corneal endotheliitis but may also have the potential to treat bullous keratopathy.
目的
我们描述了一例由巨细胞病毒（CMV）引起的角膜内皮炎并发大疱性角膜病变的病例，该病例经 ripasudil 滴眼液治疗后成功治愈。
方法
回顾性病例报告。
结果
一名 65 岁女性患者右眼被诊断为 CMV 相关性前葡萄膜炎，当大疱性角膜病变合并前葡萄膜炎复发时，她被转至我们医院。初始最佳矫正视力（BCVA）为 0.4（十进制视力）。尽管进行了抗 CMV 治疗，但她的病情并未改善，BCVA 下降至 0.07。此时，眼压（IOP）为 20mmHg，开始使用 ripasudil 滴眼液控制眼压。1 个月后，IOP 不仅降低至 14mmHg，而且角膜水肿的状况也得到改善。中央角膜厚度恢复正常，BCVA 恢复至 0.8。
结论
Ripasudil 滴眼液不仅可以降低 CMV 角膜内皮炎患者的眼压，而且可能具有治疗大疱性角膜病变的潜力。
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