Banning J W, Abramson H N, Wormser H C, Wu J D, Corbett T H
Cancer Chemother Pharmacol. 1987;19(3):207-12. doi: 10.1007/BF00252974.
The cardiotoxicity and cytotoxicity for tumor cells of four new synthetic anthraquinonyl glucosaminosides were compared in vitro. The nonhydroxylated anthraquinone was not cardiotoxic, and its cytotoxic activity was the weakest of the compounds in the series. Increasing the number of hydroxyl groups on the anthraquinone moiety increased the inhibition of growth of L-1210 leukemia cells and pancreatic or colonic adenocarcinomas in a soft agar colony formation assay. However, cardiotoxicity was also increased in proportion to the number of hydroxyl groups present. The adenocarcinomas were slightly more sensitive than the leukemias to the inhibitory action of the dihydroxylated anthraquinonyl glucosaminosides on cell growth.
在体外比较了四种新合成的蒽醌基葡糖胺苷对肿瘤细胞的心脏毒性和细胞毒性。未羟基化的蒽醌没有心脏毒性，并且其细胞毒性活性是该系列化合物中最弱的。在软琼脂集落形成试验中，增加蒽醌部分上的羟基数量可增强对L-1210白血病细胞以及胰腺或结肠腺癌生长的抑制作用。然而，心脏毒性也随着存在的羟基数量成比例增加。二羟基化蒽醌基葡糖胺苷对细胞生长的抑制作用，使腺癌比白血病略敏感。
