Kocaeli Derince Education and Research Hospital Ophthalmology Department, İbni Sina, Lojman Sk., 41900, Derince, Kocaeli, Turkey.
Gaziantep University Hospital Ophthalmology Department, Gaziantep, Turkey.
Int Ophthalmol. 2022 Apr;42(4):1273-1280. doi: 10.1007/s10792-021-02114-3. Epub 2021 Nov 2.
To evaluate the outcomes of corneal collagen cross-linking performed with customized epithelial debridement technique in progressive keratoconic corneas.
Forty eyes of 40 patients were included in the study. We performed an ophthalmologic examination and recorded the uncorrected visual acuity, best corrected visual acuity (BCVA), central corneal thickness at the thinnest point (t-CCT), flat meridian keratometry (K1), steep meridian keratometry (K2), endothelial cell density (ECC), hexagonal cells (HEX), and coefficient of variation of cell areas (CV) measured preoperatively and at the 1st, 3rd, 6th and 12th months postoperatively.
The mean UCVA and BCVA were increased (p < 0.05). The mean flattest and steepest K readings were decreased (p < 0.05). The mean t-CCT decreased in the first months after treatment and increased after 6 months. The mean t-CCT was thicker at 12 months compared to pretreatment status (p < 0.05). The mean ECC and CV were not significantly different between follow-up intervals (p > 0.05). The mean HEX was statistically increased (p > 0.05).
Corneal collagen cross-linking performed with customized epithelial debridement technique is a successful alternative method for stopping the progression of keratoconus after 12 months of treatment.
评估采用定制上皮清创术的角膜胶原交联术在进展性圆锥角膜中的治疗效果。
本研究纳入了 40 例（40 只眼）患者。我们进行了眼科检查并记录了未矫正视力（UCVA）、最佳矫正视力（BCVA）、最薄点中央角膜厚度（t-CCT）、平子午线角膜曲率（K1）、陡子午线角膜曲率（K2）、内皮细胞密度（ECC）、六边形细胞（HEX）和细胞面积变异系数（CV），所有数据均在术前以及术后第 1、3、6 和 12 个月进行测量。
平均 UCVA 和 BCVA 均增加（p<0.05）。平均最平坦和最陡峭 K 值读数降低（p<0.05）。治疗后最初几个月 t-CCT 降低，6 个月后增加。与术前相比，12 个月时 t-CCT 平均值更厚（p<0.05）。随访期间平均 ECC 和 CV 无显著差异（p>0.05）。平均 HEX 统计学上增加（p>0.05）。
采用定制上皮清创术的角膜胶原交联术是治疗圆锥角膜进展的一种成功替代方法，治疗 12 个月后可有效阻止病情进展。
