Cagil Nurullah, Sarac Ozge, Can Gamze Dereli, Akcay Emine, Can Mehmet Erol
Department of Ophthalmology, Ankara Ataturk Training and Research Hospital, Yildirim Beyazit University, Bilkent, Ankara, Turkey.
Department of Ophthalmology, Ankara Kecioren Training and Research Hospital, Ankara, Turkey.
Int Ophthalmol. 2017 Feb;37(1):103-109. doi: 10.1007/s10792-016-0234-3. Epub 2016 Apr 21.
The purpose of the study was to evaluate the outcomes and possible complications of CXL performed with customized epithelial debridement technique to keratoconic corneas with the thinnest pachymetry values less than 400 µm. Nineteen eyes of 19 patients were included. The uncorrected (UCVA) and best corrected visual acuity (BCVA), flattest and steepest keratometric (K) readings, central corneal thickness at the thinnest point (t-CCT), endothelial cell density (ECD) were assessed before and 12 months after CXL. The mean UCVA was increased (p = 0.001), while the mean BCVA did not show any difference (p > 0.05). The mean flattest and steepest K readings were decreased (p = 0.001). No change was observed in the mean t-CCT (p > 0.05). The mean ECD was decreased (p = 0.001). The mean pre-CXL and post-CXL percentages of polymegathism and pleomorphism did not show any significant difference (p > 0.05). CXL performed with customized epithelial debridement technique is successful in halting the progression of keratoconus in corneas thinner than 400 µm after 12 months of treatment. However, significant endothelial cell loss can occur after this procedure.
本研究的目的是评估采用定制上皮清创技术对最薄角膜厚度值小于400 µm的圆锥角膜进行角膜交联术（CXL）的效果及可能出现的并发症。纳入了19例患者的19只眼。在CXL术前及术后12个月评估未矫正视力（UCVA）、最佳矫正视力（BCVA）、最平及最陡角膜曲率计（K）读数、最薄点的中央角膜厚度（t-CCT）、内皮细胞密度（ECD）。平均UCVA提高了（p = 0.001），而平均BCVA未显示任何差异（p > 0.05）。平均最平及最陡K读数降低了（p = 0.001）。平均t-CCT未观察到变化（p > 0.05）。平均ECD降低了（p = 0.001）。CXL术前及术后多形性和异形性的平均百分比未显示任何显著差异（p > 0.05）。采用定制上皮清创技术进行的CXL在治疗12个月后成功阻止了厚度小于400 µm的圆锥角膜的进展。然而，该手术后可能会发生显著的内皮细胞丢失。
