De Braekeleer M
Cytogenet Cell Genet. 1987;44(4):215-22. doi: 10.1159/000132374.
Up to the beginning of 1986, some 327 variant Philadelphia translocations were reported in chronic myeloid leukemia. The present study represents an attempt to determine which factors (sex, age, geographic localization, etc.) influence the occurrence and chromosome involvement of these variant Philadelphia (Ph1) translocations. Clinical data indicated that band 9q34 was always rearranged in the variant Ph1 translocations and no difference existed between the hematologic and prognostic features among patients with the standard and the variant translocations. An uneven geographic distribution of the variant Ph1 translocations was found. Whether this was due to populations with different ethnic backgrounds or to environmental factors could not be determined. Twenty-eight bands were shown to be rearranged more frequently than expected (P less than 0.05); 27 of them are known to contain a fragile site and/or an oncogene and/or are rearranged more frequently than expected in other malignancies. The chromosomes involved in these variant Ph1 translocations were found to show a very particular geographic distribution, which cannot be explained at present.
到1986年初，慢性粒细胞白血病中报告了约327种费城染色体易位变异型。本研究旨在确定哪些因素（性别、年龄、地理分布等）会影响这些费城染色体易位变异型（Ph1）的发生和染色体受累情况。临床数据表明，在Ph1易位变异型中9q34带总是发生重排，标准型和变异型易位患者的血液学特征和预后特征并无差异。发现Ph1易位变异型存在不均衡的地理分布。这是由于不同种族背景的人群还是环境因素所致尚无法确定。有28条带的重排频率高于预期（P小于0.05）；其中27条带已知含有脆性位点和/或癌基因，和/或在其他恶性肿瘤中的重排频率高于预期。发现这些Ph1易位变异型所涉及的染色体呈现出一种非常特殊的地理分布，目前尚无法解释。
