FtsK和SpoIIIE，细菌中染色体分离和包膜重塑的协调因子。
FtsK and SpoIIIE, coordinators of chromosome segregation and envelope remodeling in bacteria.
作者信息
Chan Helena, Mohamed Ahmed M T, Grainge Ian, Rodrigues Christopher D A
机构信息
iThree Institute, University of Technology, Sydney, NSW, Australia.
School of Environmental and Life Sciences, University of Newcastle, NSW, Australia.
出版信息
Trends Microbiol. 2022 May;30(5):480-494. doi: 10.1016/j.tim.2021.10.002. Epub 2021 Oct 30.
The translocation of DNA during bacterial cytokinesis is mediated by the SpoIIIE/FtsK family of proteins. These proteins ensure efficient chromosome segregation into sister cells by ATP-driven translocation of DNA and they control chromosome dimer resolution. How FtsK/SpoIIIE mediate chromosome translocation during cytokinesis in Gram-positive and Gram-negative organisms has been the subject of debate. Studies on FtsK in Escherichia coli, and recent work on SpoIIIE in Bacillus subtilis, have identified interactions between each translocase and the division machinery, supporting the idea that SpoIIIE and FtsK coordinate the final steps of cytokinesis with completion of chromosome segregation. Here we summarize and discuss the view that SpoIIIE and FtsK play similar roles in coordinating cytokinesis with chromosome segregation, during growth and differentiation.
细菌胞质分裂过程中DNA的易位由SpoIIIE/FtsK蛋白家族介导。这些蛋白通过ATP驱动的DNA易位确保染色体高效分离到子细胞中，并控制染色体二聚体的拆分。FtsK/SpoIIIE如何在革兰氏阳性菌和革兰氏阴性菌的胞质分裂过程中介导染色体易位一直是一个争论的话题。对大肠杆菌中FtsK的研究以及最近对枯草芽孢杆菌中SpoIIIE的研究，已经确定了每种转位酶与分裂机制之间的相互作用，支持了SpoIIIE和FtsK在胞质分裂的最后步骤与染色体分离完成过程中进行协调的观点。在这里，我们总结并讨论了SpoIIIE和FtsK在生长和分化过程中，在协调胞质分裂与染色体分离方面发挥相似作用的观点。
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