副交感神经唤醒相关活动对首发精神病患者和对照受试者认知表现的影响。
Contributions of Parasympathetic Arousal-Related Activity to Cognitive Performance in Patients With First-Episode Psychosis and Control Subjects.
机构信息
Department of Psychiatry, Zucker Hillside Hospital, Glen Oaks, New York; Center for Psychiatric Neuroscience, Feinstein Institute for Medical Research, Manhasset, New York; Department of Psychiatry, Zucker School of Medicine at Hofstra/Northwell, Hofstra University, Hempstead, New York.
Department of Psychiatry, Zucker Hillside Hospital, Glen Oaks, New York; Center for Psychiatric Neuroscience, Feinstein Institute for Medical Research, Manhasset, New York; Department of Psychiatry, Zucker School of Medicine at Hofstra/Northwell, Hofstra University, Hempstead, New York.
出版信息
Biol Psychiatry Cogn Neurosci Neuroimaging. 2023 Feb;8(2):181-188. doi: 10.1016/j.bpsc.2021.10.013. Epub 2021 Oct 30.
BACKGROUND
Cognitive impairment is integral to the pathophysiology of psychosis. Recent findings implicate autonomic arousal-related activity in both momentary fluctuations and individual differences in cognitive performance. Although altered autonomic arousal is common in patients with first-episode psychosis (FEP), its contribution to cognitive performance is unknown.
METHODS
A total of 24 patients with FEP (46% male, age = 24.31 [SD 4.27] years) and 24 control subjects (42% male, age = 27.06 [3.44] years) performed the Multi-Source Interference Task in-scanner with simultaneous pulse oximetry. First-level models included the cardiac-blood oxygen level-dependent regressor, in addition to task (congruent, interference, and error) and nuisance (motion and CompCor physiology) regressors. The cardiac-blood oxygen level-dependent regressor reflected parasympathetic arousal-related activity and was created by convolving the interbeat interval at each heartbeat with the hemodynamic response function. Group models examined the effect of group or cognitive performance (reaction times × error rate) on arousal-related and task activity, while controlling for sex, age, and framewise displacement.
RESULTS
Parasympathetic arousal-related activity was robust in both groups but localized to different regions for patients with FEP and healthy control subjects. Within both groups, arousal-related activity was significantly associated with cognitive performance across occipital and temporal cortical regions. Greater arousal-related activity in the bilateral prefrontal cortex (Brodmann area 9) was related to better performance in healthy control subjects but not patients with FEP.
CONCLUSIONS
Autonomic arousal circuits contribute to cognitive performance and the pathophysiology of FEP. Arousal-related functional activity is a novel indicator of cognitive ability and should be incorporated into neurobiological models of cognition in psychosis.
背景
认知障碍是精神病病理生理学的一个组成部分。最近的研究结果表明，自主唤醒相关活动既与认知表现的瞬间波动有关，也与个体差异有关。尽管首次发作精神病（FEP）患者中自主唤醒会发生改变，但它对认知表现的贡献尚不清楚。
方法
共有 24 名 FEP 患者（46%为男性，年龄=24.31[4.27]岁）和 24 名健康对照者（42%为男性，年龄=27.06[3.44]岁）在扫描仪内同时进行血氧水平依赖脉冲血氧计同步多源干扰任务。一级模型包括心脏-血氧水平依赖回归子，除任务（一致、干扰和错误）和干扰（运动和 CompCor 生理学）回归子外。心脏-血氧水平依赖回归子反映了副交感神经唤醒相关活动，通过在每个心跳的心动间隔上卷积血流动力学响应函数来创建。组模型检查了组或认知表现（反应时间×错误率）对唤醒相关和任务活动的影响，同时控制了性别、年龄和框架位移。
结果
两组患者的副交感神经唤醒相关活动都很强烈，但 FEP 患者和健康对照组的定位区域不同。在两组中，唤醒相关活动与枕叶和颞叶皮质区域的认知表现显著相关。双侧前额叶皮质（Brodmann 区 9）的唤醒相关活动增加与健康对照组的表现更好相关，但与 FEP 患者无关。
结论
自主唤醒回路有助于认知表现和 FEP 的病理生理学。唤醒相关的功能活动是认知能力的一个新指标，应该被纳入精神病认知的神经生物学模型。
Zotero 插件