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m6A demethylase FTO attenuates cardiac dysfunction by regulating glucose uptake and glycolysis in mice with pressure overload-induced heart failure.

作者信息

Zhang Beijian, Jiang Hao, Wu Jian, Cai Yun, Dong Zhen, Zhao Yongchao, Hu Qinfeng, Hu Kai, Sun Aijun, Ge Junbo

机构信息

Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai, China.

Shanghai Institute of Cardiovascular Diseases, Shanghai, China.

出版信息

Signal Transduct Target Ther. 2021 Nov 2;6(1):377. doi: 10.1038/s41392-021-00699-w.

DOI:10.1038/s41392-021-00699-w
PMID:34728610
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8563751/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eb83/8563751/14f76ee528fc/41392_2021_699_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eb83/8563751/14f76ee528fc/41392_2021_699_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eb83/8563751/14f76ee528fc/41392_2021_699_Fig1_HTML.jpg

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本文引用的文献

1
Selecting heart failure patients for metabolic interventions.选择心力衰竭患者进行代谢干预。
Expert Rev Mol Diagn. 2017 Feb;17(2):141-152. doi: 10.1080/14737159.2017.1266939. Epub 2016 Dec 28.
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Post-transcriptional gene regulation by mRNA modifications.mRNA修饰介导的转录后基因调控。
Nat Rev Mol Cell Biol. 2017 Jan;18(1):31-42. doi: 10.1038/nrm.2016.132. Epub 2016 Nov 3.
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Cardiac metabolism in heart failure: implications beyond ATP production.心力衰竭中的心脏代谢：超越 ATP 生成的意义。
内脏器官纤维化疾病中的m6A核糖核酸甲基化
Small Sci. 2024 Nov 21;5(2):2400308. doi: 10.1002/smsc.202400308. eCollection 2025 Feb.
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Novel Insight of N6-Methyladenosine in Cardiovascular System.N6-甲基腺苷在心血管系统中的新见解
Medicina (Kaunas). 2025 Jan 26;61(2):222. doi: 10.3390/medicina61020222.
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FTO-associated osteoclastogenesis promotes alveolar bone resorption in apical periodontitis male rat via the HK1/USP14/RANK pathway.FTO相关的破骨细胞生成通过HK1/USP14/RANK途径促进根尖周炎雄性大鼠的牙槽骨吸收。
Nat Commun. 2025 Feb 11;16(1):1519. doi: 10.1038/s41467-025-56615-1.
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YTHDF3-mediated FLCN/cPLA2 axis improves cardiac fibrosis via suppressing lysosomal function.YTHDF3介导的FLCN/cPLA2轴通过抑制溶酶体功能改善心脏纤维化。
Acta Pharmacol Sin. 2025 May;46(5):1262-1274. doi: 10.1038/s41401-024-01425-2. Epub 2025 Jan 13.
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FTO in health and disease.健康与疾病中的FTO
Front Cell Dev Biol. 2024 Dec 18;12:1500394. doi: 10.3389/fcell.2024.1500394. eCollection 2024.
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YTHDC1 Regulates the Migration, Invasion, Proliferation, and Apoptosis of Rheumatoid Fibroblast-Like Synoviocytes.YTHDC1 调控类风湿关节炎成纤维样滑膜细胞的迁移、侵袭、增殖和凋亡。
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Glycolysis modulation: New therapeutic strategies to improve pulmonary hypertension (Review).糖酵解调节：改善肺动脉高压的新治疗策略（综述）。
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Identification of a common gene expression signature in dilated cardiomyopathy across independent microarray studies.通过独立的微阵列研究鉴定扩张型心肌病中的常见基因表达特征。
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