COVID-19 Response, Centers for Disease Control and Prevention, Atlanta, GA, USA.
U.S. Department of Energy, Oak Ridge Institute for Science and Education, Oak Ridge, TN, USA.
J Perinatol. 2022 Apr;42(4):446-453. doi: 10.1038/s41372-021-01243-y. Epub 2021 Nov 2.
To better understand COVID-19 in newborns, we compared in-hospital illness severity indicators by COVID-19 status during birth hospitalization.
In a retrospective cohort of newborns born March-December 2020 in the Premier Healthcare Database Special COVID-19 Release, we classified COVID-19 status and severe illness indicators using ICD-CM-10 codes, laboratory data, and billing records. Illness severity indicators were compared by COVID-19 status, stratified by gestational age and race/ethnicity.
Among 701,777 newborns, 209 had a COVID-19 diagnosis during the birth hospitalization. COVID-19 status differed significantly by race/ethnicity, gestational age, payor, and region. Late preterm/term newborns with COVID-19 had increased intensive care unit admission and sepsis risk; early preterm newborns with COVID-19 had increased risk for invasive ventilation. Risk for illness severity varied among racial/ethnic strata.
From March to December 2020, COVID-19 diagnosis in newborns was rare. More clinical data are needed to describe the risk profiles of newborns with COVID-19.
为了更好地了解新生儿中的 COVID-19，我们比较了分娩住院期间 COVID-19 状态的住院疾病严重程度指标。
在 Premier Healthcare Database Special COVID-19 Release 中，我们对 2020 年 3 月至 12 月期间出生的新生儿进行了回顾性队列研究，使用 ICD-CM-10 代码、实验室数据和计费记录对 COVID-19 状态和严重疾病指标进行分类。根据胎龄和种族/民族对疾病严重程度指标进行分层，比较 COVID-19 状态。
在 701777 名新生儿中，有 209 名在分娩住院期间被诊断为 COVID-19。COVID-19 状态在种族/民族、胎龄、付款人和地区方面存在显著差异。患有 COVID-19 的晚期早产儿/足月新生儿入住重症监护病房和发生败血症的风险增加；患有 COVID-19 的早期早产儿有更高的有创通气风险。疾病严重程度的风险在不同种族/民族群体中存在差异。
2020 年 3 月至 12 月期间，新生儿 COVID-19 诊断罕见。需要更多的临床数据来描述 COVID-19 新生儿的风险特征。
