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Commentary: PROTACs make undruggable targets druggable: Challenge and opportunity.

作者信息

Lu Bin, Ye Jianpin

机构信息

The Second Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang 421001, China.

Protein Quality Control and Diseases Laboratory, School of Laboratory Medicine and Life Sciences, Wenzhou Medical University, Wenzhou 325035, China.

出版信息

Acta Pharm Sin B. 2021 Oct;11(10):3335-3336. doi: 10.1016/j.apsb.2021.07.017. Epub 2021 Jul 22.

Abstract
摘要

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Targeted protein degraders crowd into the clinic.靶向蛋白降解剂纷纷涌入临床。
Nat Rev Drug Discov. 2021 Apr;20(4):247-250. doi: 10.1038/d41573-021-00052-4.
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Targeted protein degradation: expanding the toolbox.靶向蛋白降解:拓展工具盒。
Nat Rev Drug Discov. 2019 Dec;18(12):949-963. doi: 10.1038/s41573-019-0047-y. Epub 2019 Oct 30.

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