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Commentary: PROTACs make undruggable targets druggable: Challenge and opportunity.

作者信息

Lu Bin, Ye Jianpin

机构信息

The Second Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang 421001, China.

Protein Quality Control and Diseases Laboratory, School of Laboratory Medicine and Life Sciences, Wenzhou Medical University, Wenzhou 325035, China.

出版信息

Acta Pharm Sin B. 2021 Oct;11(10):3335-3336. doi: 10.1016/j.apsb.2021.07.017. Epub 2021 Jul 22.

DOI:10.1016/j.apsb.2021.07.017
PMID:34729320
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8546888/
Abstract
摘要

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本文引用的文献

1
Proteolysis targeting chimeras (PROTACs) come of age: entering the third decade of targeted protein degradation.靶向蛋白降解嵌合体（PROTACs）步入成熟：进入靶向蛋白降解的第三个十年。
RSC Chem Biol. 2021 Mar 19;2(3):725-742. doi: 10.1039/d1cb00011j.
2
Maintenance of organellar protein homeostasis by ER-associated degradation and related mechanisms.内质网相关降解及相关机制维持细胞器蛋白的稳态。
Mol Cell. 2021 Jun 17;81(12):2507-2519. doi: 10.1016/j.molcel.2021.05.004. Epub 2021 Jun 8.
3
Targeted protein degradation: A promise for undruggable proteins.靶向蛋白降解：不可成药蛋白的新希望。
Cell Chem Biol. 2021 Jul 15;28(7):934-951. doi: 10.1016/j.chembiol.2021.04.011. Epub 2021 May 17.
4
Targeted protein degraders crowd into the clinic.靶向蛋白降解剂纷纷涌入临床。
Nat Rev Drug Discov. 2021 Apr;20(4):247-250. doi: 10.1038/d41573-021-00052-4.
5
Clinical Review: Navitoclax as a Pro-Apoptotic and Anti-Fibrotic Agent.临床综述：维托克洛司作为一种促凋亡和抗纤维化药物
Front Pharmacol. 2020 Nov 26;11:564108. doi: 10.3389/fphar.2020.564108. eCollection 2020.
6
PROTACs: An Emerging Therapeutic Modality in Precision Medicine.蛋白水解靶向嵌合体（PROTACs）：精准医学中的一种新兴治疗模式。
Cell Chem Biol. 2020 Aug 20;27(8):998-1014. doi: 10.1016/j.chembiol.2020.07.020. Epub 2020 Aug 13.
7
Proteolysis-Targeting Chimeras as Therapeutics and Tools for Biological Discovery.蛋白水解靶向嵌合体作为治疗方法和生物发现工具。
Cell. 2020 Apr 2;181(1):102-114. doi: 10.1016/j.cell.2019.11.031. Epub 2020 Jan 16.
8
A selective BCL-X PROTAC degrader achieves safe and potent antitumor activity.一种选择性 BCL-XL PROTAC 降解剂可实现安全有效的抗肿瘤活性。
Nat Med. 2019 Dec;25(12):1938-1947. doi: 10.1038/s41591-019-0668-z. Epub 2019 Dec 2.
9
Cellular quality control by the ubiquitin-proteasome system and autophagy.细胞的泛素-蛋白酶体系统和自噬的质量控制。
Science. 2019 Nov 15;366(6467):818-822. doi: 10.1126/science.aax3769. Epub 2019 Nov 14.
10
Targeted protein degradation: expanding the toolbox.靶向蛋白降解：拓展工具盒。
Nat Rev Drug Discov. 2019 Dec;18(12):949-963. doi: 10.1038/s41573-019-0047-y. Epub 2019 Oct 30.