饮食在慢性肾脏病骨矿物质代谢紊乱中的作用的最新进展。
Recent Advances in the Role of Diet in Bone and Mineral Disorders in Chronic Kidney Disease.
机构信息
Division of Nephrology, Department of Medicine, School of Medicine, University of Alabama at Birmingham, THT 647, 1720 2nd AVE S, Birmingham, AL, 35294-0006, USA.
Department of Epidemiology, School of Public Health, University of Alabama at Birmingham, THT 647, 1720 2nd AVE S, Birmingham, AL, 35294-0006, USA.
出版信息
Curr Osteoporos Rep. 2021 Dec;19(6):574-579. doi: 10.1007/s11914-021-00710-x. Epub 2021 Nov 3.
PURPOSE OF REVIEW
Chronic kidney disease mineral and bone disease (CKD-MBD) is a common complication of kidney disease and is strongly influenced by diet. The purpose of this manuscript is to review recent advances in the role of diet in CKD-MBD over the last 5 years.
RECENT FINDINGS
Many of the recent studies examining the role of diet in CKD-MBD have focused on the adverse effects of high phosphorus consumption on bone health and metabolism. In general, the studies have shown that high phosphorus consumption worsens markers of bone and mineral metabolism but that eating a diet with a calcium to phosphorus ratio closer to 1:1 can attenuate some of these effects. Recent studies also showed that dietary counseling is efficacious for improving markers of CKD-MBD. High consumption of phosphorus aggravates CKD-MBD. Dietary counseling may ameliorate these effects, for example, by consuming diets with higher calcium to phosphorus ratios.
目的综述
慢性肾脏病矿物质和骨代谢异常（CKD-MBD）是肾脏疾病的常见并发症，且强烈受饮食影响。本文旨在综述过去 5 年中饮食在 CKD-MBD 中的作用的最新进展。
最近发现
许多研究饮食在 CKD-MBD 中的作用的最新研究都集中在高磷摄入对骨骼健康和代谢的不良影响上。总的来说，这些研究表明，高磷摄入会使骨骼和矿物质代谢的标志物恶化，但食用钙磷比接近 1:1 的饮食可以减轻其中一些影响。最近的研究还表明，饮食咨询对改善 CKD-MBD 的标志物有效。高磷摄入会加重 CKD-MBD。饮食咨询可以通过摄入钙磷比更高的饮食来改善这些影响。
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