Kucharski P, Kiełbowicz Z
Department and Clinic of Surgery, Faculty of Veterinary Medicine, Wroclaw University of Environment and Life Sciences, Pl. Grunwaldzki 51, Wrocław 50-336, Poland.
Pol J Vet Sci. 2021 Sep;24(3):451-459. doi: 10.24425/pjvs.2021.138738.
This article is an attempt to gather available literature regarding the use of tiletamine and zolazepam combination in anaesthesia in dogs and cats. Although tiletamine and zolazepam mixture has been known in veterinary practice for a long time, the increased interest in these drugs has been observed only recently. Tiletamine, similarly to ketamine, is a drug which belongs to the phencyclidine group. Ketamine has considerable popularity in veterinary practice what suggests that other dissociative anaesthetic drugs, such as tiletamine, could also prove effective in cats' and dogs' anaesthetic care. Zolazepam is a widely used benzodiazepine known for its muscle relaxant and anticonvulsant properties. While conducting an electronic search for articles regarding the use of tiletamine-zolazepam combination in dogs and cats, it has been discovered that the literature on the subject (tiletamine-zolazepam combination in dogs and cats) is quite scarce. Very few articles were published after 2010. Databases used were: Google Scholar, Scopus, PubMed. Most of the adverse effects, including those affecting the cardiovascular, nervous, and respiratory systems, were strictly dose-dependent. Tiletamine-zolazepam combination can be safely used as a premedication agent, induction for inhalation anaesthesia, or an independent anaesthetic for short procedures. Contraindications using tiletamine-zolazepam mixture include central nervous system (CNS) diseases such as epilepsy and seizures, head trauma, penetrative eye trauma, cardiovascular abnormalities (hypertrophy cardiomyopathy in cats, arrythmias or conditions where increase of heart rate is inadvisable), hyperthyroidism, pancreatic deficiencies or kidney failure.
本文旨在收集有关替来他明与唑拉西泮联合用于犬猫麻醉的现有文献。尽管替来他明与唑拉西泮的混合物在兽医实践中已为人所知很长时间，但对这些药物的兴趣增加只是最近才被观察到。替来他明与氯胺酮类似，是一种属于苯环己哌啶类的药物。氯胺酮在兽医实践中非常受欢迎，这表明其他解离性麻醉药物，如替来他明，在犬猫麻醉护理中也可能被证明是有效的。唑拉西泮是一种广泛使用的苯二氮䓬类药物，以其肌肉松弛和抗惊厥特性而闻名。在通过电子搜索有关替来他明 - 唑拉西泮联合用于犬猫的文章时，发现关于该主题（犬猫的替来他明 - 唑拉西泮联合用药）的文献相当稀少。2010年后发表的文章很少。使用的数据库有：谷歌学术、Scopus、PubMed。大多数不良反应，包括影响心血管系统（CVS）、神经系统和呼吸系统的不良反应，都严格依赖于剂量。替来他明 - 唑拉西泮联合用药可以安全地用作术前用药、吸入麻醉诱导剂或短时间手术的独立麻醉剂。使用替来他明 - 唑拉西泮混合物的禁忌症包括中枢神经系统（CNS）疾病，如癫痫和惊厥、头部外伤、穿透性眼外伤、心血管异常（猫的肥厚性心肌病、心律失常或不适合心率增加的情况）、甲状腺功能亢进、胰腺功能不全或肾衰竭。
