Wang Chi-Hui, Lin Yu-Jr, Hu Sindy, Huang Yao-Li, Chung Wen-Hung, Ng Chau Yee
Department of Dermatology, Chang Gung Memorial Hospital, Taoyuan, Taiwan.
Department of Biomedical Engineering, Chung Yuan Christian University, Chung-Li, Taiwan.
J Cosmet Dermatol. 2022 Jul;21(7):2924-2930. doi: 10.1111/jocd.14548. Epub 2021 Nov 3.
Vitiligo is a common, psychologically devastating pigmentary disorder. Surgical graftings are used to treat stable vitiligo when medical treatment fails. An automated epidermal micrograft harvesting (AEMH) system was first designated to treat wounds, and very few studies investigated the application of AEMH in vitiligo. In this study, we investigated the efficacy and safety of the AEMH system in patients with stable segmental and nonsegmental vitiligo. The rate of repigmentation and adverse events was recorded bimonthly for at least 12 months. We analyzed the efficacy based on patient characteristics, vitiligo subtypes, and different anatomical locations. A total of 56 depigmented lesions from 34 patients were included. 95.50% of the automated epidermal micrografts were successfully grafted at the recipient sites. There was a significant improvement in Vitiligo Area Scoring Index (VASI) and Dermatologic Life Quality Index (DLQI) in patients treated with AEMH (p < 0.001). The rate of repigmentation by VASI score improves from 96.25 ± 8.59 to 48.30 ± 28.16 after the treatment (p < 0.001). Treatment outcomes were comparable between the patients of segmental and stable nonsegmental vitiligo. The face and neck region achieved a better outcome, followed by the trunk (chest, abdomen, back, and axilla), limbs, and the worse outcome was found in the acral region (p < 0.014). Conclusively, AEMH is an effective treatment procedure with limited adverse events in patients with stable vitiligo. This harvesting method may be a feasible option for vitiligo surgical treatment.
白癜风是一种常见的、对心理有严重影响的色素沉着障碍性疾病。当药物治疗无效时，手术移植可用于治疗稳定期白癜风。自动表皮微移植采集（AEMH）系统最初是用于治疗伤口的，很少有研究探讨其在白癜风治疗中的应用。在本研究中，我们调查了AEMH系统治疗稳定期节段型和非节段型白癜风患者的疗效和安全性。每两个月记录一次色素再生率和不良事件，至少记录12个月。我们根据患者特征、白癜风亚型和不同解剖部位分析疗效。共纳入34例患者的56个色素脱失性皮损。95.50%的自动表皮微移植成功移植到受区。接受AEMH治疗的患者白癜风面积评分指数（VASI）和皮肤病生活质量指数（DLQI）有显著改善（p<0.001）。治疗后，VASI评分的色素再生率从96.25±8.59提高到48.30±28.16（p<0.001）。节段型和稳定期非节段型白癜风患者的治疗效果相当。面部和颈部区域的治疗效果较好，其次是躯干（胸部、腹部、背部和腋窝）、四肢，而肢端区域的治疗效果最差（p<0.014）。总之，AEMH是一种治疗稳定期白癜风患者有效的治疗方法，不良事件有限。这种采集方法可能是白癜风手术治疗的一种可行选择。
