Department of Dermatology, Chang Gung Memorial Hospital, Linkou Branch, No.5, Fushin Street, Taoyuan, Keelung Branch, Linkou, Taipei, Taiwan.
College of Medicine, Chang Gung University, Taoyuan, Taiwan.
Sci Rep. 2022 Jan 10;12(1):393. doi: 10.1038/s41598-021-04299-0.
The automated blister epidermal micrograft (ABEM) is a newly introduced surgical transplantation for refractory vitiligo. Comparative analysis of other surgical methods is lacking. We conducted a retrospective study to compare the efficacy, safety, and experience of ABEM with conventional suction blister epidermal graft (SBEG). A total of 118 anatomically based vitiligo lesions from 75 patients were included. The primary outcome was the degree of repigmentation; the patient and operator experience were evaluated. SBEG had a significantly greater incidence of repigmentation (p < 0.001), as measured by the Physician Global Assessment, as well as improvements in the Vitiligo Area Scoring Index, particularly on the face/neck area (p < 0.001). ABEM, on the contrary, had reduced donor harvest time, a better patient operative experience, and more significant Dermatology Life Quality Index improvements. In a subgroup of 38 lesions from ten patients who received both SBEG and ABEM concomitantly, there was no difference in the degree of repigmentation in the same recipient area. Overall, the degree of repigmentation for SBEG is higher than ABEM, especially in the mobilized region, and the cost is less expensive. On the contrary, ABEM requires less procedure learning curve and can supply a greater transplanting zone with shorter donor site recovery. Understanding the benefits and drawbacks of two blister grafting procedures is essential for optimal surgical outcomes for vitiligo grafting.
自动水疱表皮微移植（ABEM）是一种新引入的难治性白癜风外科移植方法。缺乏对其他手术方法的比较分析。我们进行了一项回顾性研究，比较了 ABEM 与常规吸疱表皮移植（SBEG）在疗效、安全性和经验方面的差异。共纳入 75 例患者的 118 个解剖学基础的白癜风病变。主要结局是复色程度；评估了患者和操作者的经验。SBEG 的复色程度显著更高（p<0.001），这是根据医生总体评估得出的，并且在白癜风面积评分指数上也有改善，特别是在面部/颈部区域（p<0.001）。相反，ABEM 减少了供体采集时间，患者手术体验更好，皮肤病生活质量指数改善更明显。在十个同时接受 SBEG 和 ABEM 的患者的 38 个病变的亚组中，同一受区的复色程度没有差异。总的来说，SBEG 的复色程度高于 ABEM，尤其是在动员区域，且成本更低。相反，ABEM 所需的手术学习曲线更少，可以用较短的供区恢复时间提供更大的移植区。了解两种水疱移植程序的优缺点对于获得最佳的白癜风移植手术效果至关重要。
