Freelance Dermatologists, Rome, Italy.
Salus RSA, Nursing Home, Rome, Italy.
J Cosmet Dermatol. 2021 Dec;20(12):3747-3750. doi: 10.1111/jocd.14549. Epub 2021 Nov 3.
COVID-19 is associated with several cutaneous manifestations, including chilbain-like lesions, urticaria, erythema multiforme, and maculopapular lesions. Dermatoses may be directly linked to the viral infection or also represent a consequence of systemic therapies administrated for COVID-19. A potential role of SARS-CoV-2 in triggering the reactivation of other viruses, such as HHV-6, HHV-7 and Epstein-Barr virus has been hypothesized.
To better understand and hypothesize possible pathogenetic correlations of COVID-19 with other dermatological conditions.
We report the case of an 83-year-old woman hospitalized in a nursing home for several years. On November 2020, the patient had been diagnosed with SARS-CoV-2 infection, with repeated positive swabs until January 2021. After a month, new-onset asymptomatic cutaneous purplish macular lesions and violaceous patches occurred bilaterally on the feet.
An incisional cutaneous biopsy and the histological examination of the plantar lesion revealed the diagnosis of Kaposi Sarcoma.
We report a unique case of new-onset bilateral Kaposi's sarcoma following COVID-19, speculating on a possible role of SARS-CoV-2 in the reactivation of human herpes virus-8 (HHV-8) infection.
COVID-19 与多种皮肤表现有关，包括冻疮样病变、荨麻疹、多形红斑和斑丘疹。皮肤病可能与病毒感染直接相关，也可能是 COVID-19 全身治疗的后果。有人假设 SARS-CoV-2 可能在触发其他病毒（如 HHV-6、HHV-7 和 EBV）的再激活中起作用。
更好地了解和假设 COVID-19 与其他皮肤病之间可能存在的发病机制相关性。
我们报告了一例 83 岁女性的病例，她在疗养院住院多年。2020 年 11 月，该患者被诊断出患有 SARS-CoV-2 感染，直到 2021 年 1 月连续多次咽拭子检测阳性。一个月后，双足出现无症状的紫红色斑疹性和紫红色斑块性新发性皮疹。
足底病变的切开皮肤活检和组织学检查显示卡波西肉瘤的诊断。
我们报告了一例 COVID-19 后新发双侧卡波西肉瘤的独特病例，推测 SARS-CoV-2 可能在人类疱疹病毒-8（HHV-8）感染的再激活中起作用。
