在辛德毕斯病毒持续感染的白纹伊蚊细胞培养物的培养基中发现了新型抗病毒活性。
Novel antiviral activity found in the media of Sindbis virus-persistently infected mosquito (Aedes albopictus) cell cultures.
作者信息
Riedel B, Brown D T
出版信息
J Virol. 1979 Jan;29(1):51-60. doi: 10.1128/JVI.29.1.51-60.1979.
Abstract
Aedes albopictus (mosquito) cells persistently infected with Sindbis virus for a period of 6 months release into the medium a low-molecular-weight material capable of specifically reducing the yields of Sindbis virus during the "acute phase" of infection in mosquito cells. The antiviral activity was produced in detectable levels at 3 days after infection, and its concentration in the extracellular medium increased thereafter. The antiviral activity was inactivated by treatment with the enzyme protease K and heat. It was not activated by treatment with antibody prepared against extracts of Sindbis virus-infected BHK-21 cells. The antiviral activity differs from interferon produced by vertebrate cells in that it is virus specific as well as cell specific.
摘要
白纹伊蚊（蚊子）细胞被辛德毕斯病毒持续感染6个月后，会向培养基中释放一种低分子量物质，该物质能够在蚊子细胞感染的“急性期”特异性降低辛德毕斯病毒的产量。抗病毒活性在感染后3天达到可检测水平，此后其在细胞外培养基中的浓度增加。该抗病毒活性经蛋白酶K处理和加热后失活。用针对辛德毕斯病毒感染的BHK - 21细胞提取物制备的抗体处理不能激活它。这种抗病毒活性与脊椎动物细胞产生的干扰素不同，因为它具有病毒特异性和细胞特异性。
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