在辛德毕斯病毒持续感染的白纹伊蚊细胞培养物的培养基中发现了新型抗病毒活性。
Novel antiviral activity found in the media of Sindbis virus-persistently infected mosquito (Aedes albopictus) cell cultures.
作者信息
Riedel B, Brown D T
出版信息
J Virol. 1979 Jan;29(1):51-60. doi: 10.1128/JVI.29.1.51-60.1979.
Abstract
Aedes albopictus (mosquito) cells persistently infected with Sindbis virus for a period of 6 months release into the medium a low-molecular-weight material capable of specifically reducing the yields of Sindbis virus during the "acute phase" of infection in mosquito cells. The antiviral activity was produced in detectable levels at 3 days after infection, and its concentration in the extracellular medium increased thereafter. The antiviral activity was inactivated by treatment with the enzyme protease K and heat. It was not activated by treatment with antibody prepared against extracts of Sindbis virus-infected BHK-21 cells. The antiviral activity differs from interferon produced by vertebrate cells in that it is virus specific as well as cell specific.
摘要
白纹伊蚊（蚊子）细胞被辛德毕斯病毒持续感染6个月后，会向培养基中释放一种低分子量物质，该物质能够在蚊子细胞感染的“急性期”特异性降低辛德毕斯病毒的产量。抗病毒活性在感染后3天达到可检测水平，此后其在细胞外培养基中的浓度增加。该抗病毒活性经蛋白酶K处理和加热后失活。用针对辛德毕斯病毒感染的BHK - 21细胞提取物制备的抗体处理不能激活它。这种抗病毒活性与脊椎动物细胞产生的干扰素不同，因为它具有病毒特异性和细胞特异性。
相似文献
1
Novel antiviral activity found in the media of Sindbis virus-persistently infected mosquito (Aedes albopictus) cell cultures.
J Virol. 1979 Jan;29(1):51-60. doi: 10.1128/JVI.29.1.51-60.1979.
2
Heterologous interference in Aedes albopictus cells infected with alphaviruses.
J Virol. 1979 Apr;30(1):45-55. doi: 10.1128/JVI.30.1.45-55.1979.
3
Exclusion of superinfecting homologous virus by Sindbis virus-infected Aedes albopictus (mosquito) cells.
J Virol. 1986 Apr;58(1):81-6. doi: 10.1128/JVI.58.1.81-86.1986.
4
Antiviral activity released from Aedes albopictus cells persistently infected with Semliki forest virus.
J Virol. 1983 Sep;47(3):652-5. doi: 10.1128/JVI.47.3.652-655.1983.
5
Superinfection exclusion of alphaviruses in three mosquito cell lines persistently infected with Sindbis virus.
J Virol. 1997 Sep;71(9):7119-23. doi: 10.1128/JVI.71.9.7119-7123.1997.
6
Defective interfering particles of Sindbis virus do not interfere with the homologous virus obtained from persistently infected BHK cells but do interfere with Semliki Forest virus.
J Virol. 1981 Feb;37(2):840-4. doi: 10.1128/JVI.37.2.840-844.1981.
7
Suppression of RNA synthesis by a specific antiviral activity in Sindbis virus-infected Aedes albopictus cells.
J Virol. 1988 Jan;62(1):346-8. doi: 10.1128/JVI.62.1.346-348.1988.
8
The susceptibility of isolated guts from various species of mosquito to some arboviruses.
Ann Trop Med Parasitol. 1976 Mar;70(1):95-9. doi: 10.1080/00034983.1976.11687099.
9
Characteristics of Sindbis virus temperature-sensitive mutants in cultured BHK-21 and Aedes albopictus (Mosquito) cells.
J Virol. 1976 Sep;19(3):775-81. doi: 10.1128/JVI.19.3.775-781.1976.
10
Failure of defective interfering particles of Sindbis virus produced in BHK or chicken cells to affect viral replication in Aedes albopictus cells.
J Virol. 1976 Aug;19(2):398-408. doi: 10.1128/JVI.19.2.398-408.1976.
引用本文的文献
1
Characterization of Viral Interference in C6/36 Cells Persistently Infected with Dengue Virus 2.
Pathogens. 2023 Sep 6;12(9):1135. doi: 10.3390/pathogens12091135.
2
Chikungunya virus superinfection exclusion is mediated by a block in viral replication and does not rely on non-structural protein 2.
PLoS One. 2020 Nov 12;15(11):e0241592. doi: 10.1371/journal.pone.0241592. eCollection 2020.
3
Sindbis virus interferes with dengue 4 virus replication and its potential transmission by Aedes albopictus.
Parasit Vectors. 2015 Jan 30;8:65. doi: 10.1186/s13071-015-0667-y.
4
Inducible viral receptor, A possible concept to induce viral protection in primitive immune animals.
Virol J. 2011 Jun 28;8:326. doi: 10.1186/1743-422X-8-326.
5
Response to Dengue virus infections altered by cytokine-like substances from mosquito cell cultures.
BMC Microbiol. 2010 Nov 16;10:290. doi: 10.1186/1471-2180-10-290.
6
Cell-to-cell spread of the RNA interference response suppresses Semliki Forest virus (SFV) infection of mosquito cell cultures and cannot be antagonized by SFV.
J Virol. 2009 Jun;83(11):5735-48. doi: 10.1128/JVI.02440-08. Epub 2009 Mar 18.
7
Semliki Forest virus strongly reduces mosquito host defence signaling.
Insect Mol Biol. 2008 Dec;17(6):647-56. doi: 10.1111/j.1365-2583.2008.00834.x. Epub 2008 Sep 22.
8
Biological transmission of arboviruses: reexamination of and new insights into components, mechanisms, and unique traits as well as their evolutionary trends.
Clin Microbiol Rev. 2005 Oct;18(4):608-37. doi: 10.1128/CMR.18.4.608-637.2005.
9
A single deletion in the membrane-proximal region of the Sindbis virus glycoprotein E2 endodomain blocks virus assembly.
J Virol. 2000 May;74(9):4220-8. doi: 10.1128/jvi.74.9.4220-4228.2000.
10
Persistent Hz-1 virus infection in insect cells: evidence for insertion of viral DNA into host chromosomes and viral infection in a latent status.
J Virol. 1999 Jan;73(1):128-39. doi: 10.1128/JVI.73.1.128-139.1999.
本文引用的文献
1
Amino acid metabolism in mammalian cell cultures.
Science. 1959 Aug 21;130(3373):432-7. doi: 10.1126/science.130.3373.432.
2
Arbovirus replication in mosquito cell lines (Singh) grown in monolayer or suspension culture.
Proc Soc Exp Biol Med. 1970 May;134(1):356-61. doi: 10.3181/00379727-134-34793.
3
Temperature-sensitive virus from Aedes albopictus cells chronically infected with Sindbis virus.
J Virol. 1974 Feb;13(2):439-47. doi: 10.1128/JVI.13.2.439-447.1974.
4
Homologous viral interference in Aedes albopictus cultures chronically infected with Sindbis virus.
J Virol. 1973 Apr;11(4):592-5. doi: 10.1128/JVI.11.4.592-595.1973.
5
Homologous interference in Aedes aegypti cell cultures infected with Sindbis virus.
Arch Gesamte Virusforsch. 1974;45(4):309-18. doi: 10.1007/BF01242874.
6
Observations of Aedes albopictus cell cultures persistently infected with Sindbis virus.
Ann N Y Acad Sci. 1975;266:214-31. doi: 10.1111/j.1749-6632.1975.tb35103.x.
7
Characteristics of Sindbis virus temperature-sensitive mutants in cultured BHK-21 and Aedes albopictus (Mosquito) cells.
J Virol. 1976 Sep;19(3):775-81. doi: 10.1128/JVI.19.3.775-781.1976.
8
Failure of defective interfering particles of Sindbis virus produced in BHK or chicken cells to affect viral replication in Aedes albopictus cells.
J Virol. 1976 Aug;19(2):398-408. doi: 10.1128/JVI.19.2.398-408.1976.
9
Evolution and properties of Aedes albopictus cell cultures persistently infected with sindbis virus.
Virology. 1977 Oct 1;82(1):69-83. doi: 10.1016/0042-6822(77)90033-2.
10
Role of extracellular virus on the maintenance of the persistent infection induced in Aedes albopictus (mosquito) cells by Sindbis virus.
J Virol. 1977 Sep;23(3):554-61. doi: 10.1128/JVI.23.3.554-561.1977.
Zotero 插件