National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China; Geriatric Health Care and Medical Research Center, Sichuan University, Chengdu, Sichuan Province, China.
National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China; Geriatric Health Care and Medical Research Center, Sichuan University, Chengdu, Sichuan Province, China.
J Affect Disord. 2022 Feb 1;298(Pt A):381-387. doi: 10.1016/j.jad.2021.10.083. Epub 2021 Oct 31.
To identify the prevalence, lifestyle factors, chronic disease status, and assessing the metabolic profile, comparing key differences in a cohort of subjects aged at least 50 years old among depression combined anxiety, depression and anxiety in a multi-ethnic population in west China.
A large multi-ethnic sample of 6838 participants aged 50 years old (mean age 62.4 ± 8.3 years) from West China Health and Aging Trend (WCHAT) study was analyzed. We categorized all participants into four groups: (a) comorbid anxiety and depression symptomology (CAD), (b) anxiety only, (c) depression only, or (d) neither depression nor anxiety. Different variables like anthropometry measures, life styles, chronic disease and blood test were collected. Depressive symptoms were assessed using the 15-item Geriatric Depression Scale (GDS-15). GDS-15 scores ≥5 indicate depression. Anxiety status was assessed using Generalized Anxiety Disorder (GAD-7) instrument and the scores ≥5 was considered as having anxiety. Different variables like anthropometry measures, life styles, cognitive function and chronic disease comorbidities were collected and serum parameters were tested. Multivariable logistic regression adjusted for age, sex, and ethnicity was done to compare between those with the mental outcomes and without.
The proportions of CAD, anxiety and depression were 9.0%, 12.8% and 10.6% respectively with ethnic diversity. The 'comorbid' group shown greater frequency of being female, having a lower educational level, higher prevalence of being single/divorced/widowed, drinking alcohol and smoking, more chronic disease profile and cognitive decline compared with individuals with only one disorder. And the metabolic profile showed differences in albumin, total protein, creatinine, uric acid, thyroid hormones in comparing CAD symptomology and the 'neither symptomology'.
Yi, Qiang and Uyghur ethnic groups have a higher prevalence of mental disease compared with Han in west China. And these mental disease had a distinct risk factor profile in age, sex, educational level, chronic disease and cognitive function. Vitamin D levels were lower among those with mental disease compared to those without.
在中国西部的多民族人群中，确定至少 50 岁以上人群中抑郁合并焦虑、抑郁和焦虑的患病率、生活方式因素、慢性病状况，并评估其代谢特征，比较不同亚组之间的关键差异。
对来自中国西部健康与老龄化趋势（WCHAT）研究的 6838 名 50 岁以上（平均年龄 62.4±8.3 岁）的大型多民族样本进行分析。我们将所有参与者分为四组：（a）合并焦虑和抑郁症状（CAD），（b）仅焦虑，（c）仅抑郁，或（d）既无抑郁也无焦虑。收集了不同的变量，如人体测量指标、生活方式、慢性疾病和血液检查。使用 15 项老年抑郁量表（GDS-15）评估抑郁症状。GDS-15 评分≥5 表示抑郁。使用广泛性焦虑障碍（GAD-7）量表评估焦虑状况，评分≥5 表示有焦虑。收集了不同的变量，如人体测量指标、生活方式、认知功能和慢性疾病合并症，并测试了血清参数。对年龄、性别和种族进行多变量逻辑回归，以比较有和无精神结局的人群之间的差异。
CAD、焦虑和抑郁的比例分别为 9.0%、12.8%和 10.6%，具有种族多样性。与只有一种疾病的个体相比，“合并”组女性比例更高、教育水平更低、单身/离婚/丧偶比例更高、饮酒和吸烟比例更高、慢性疾病谱和认知能力下降更为常见。与 CAD 症状相比，代谢特征在白蛋白、总蛋白、肌酐、尿酸、甲状腺激素方面存在差异。
在中国西部，彝族、羌族和维吾尔族的精神疾病患病率高于汉族。这些精神疾病在年龄、性别、教育水平、慢性疾病和认知功能方面具有明显的危险因素特征。与没有精神疾病的人相比，有精神疾病的人维生素 D 水平较低。
