初诊时软组织肉瘤脑转移。
Brain Metastasis in Soft Tissue Sarcoma at Initial Presentation.
机构信息
Department of Orthopaedic Surgery, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan.
Department of Orthopaedic Surgery, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan;
出版信息
Anticancer Res. 2021 Nov;41(11):5611-5616. doi: 10.21873/anticanres.15376.
BACKGROUND/AIM: Brain metastasis is a rare condition among patients with soft tissue sarcoma (STS), and its precise incidence remains unclear. The aim of this study was to investigate which patients should be screened for brain metastasis.
PATIENTS AND METHODS
We identified all patients with STS diagnosed between 2010 and 2015 in the SEER database. Incidence of brain metastasis at initial presentation and higher incidence of brain metastasis by histological subtype were investigated. In addition, risk factors for brain metastasis were examined.
RESULTS
A total of 26,676 patients were included for analysis, of whom 162 patients (0.6%) had brain metastasis. Alveolar soft part sarcoma (6.3%), malignant hemangioendothelioma (3.1%) and malignant schwannoma (2.6%) showed higher incidence of brain metastasis. Deep-rooted tumor, trunk tumor, and histological high-grade tumor tended to show higher incidence of brain metastasis.
CONCLUSION
Risk factors for brain metastasis were deep location, trunk development and histologically high-grade tumor, or specific histological subtypes.
背景/目的：脑转移是软组织肉瘤（STS）患者中罕见的情况，其确切发病率尚不清楚。本研究旨在探讨哪些患者应进行脑转移筛查。
患者与方法
我们在 SEER 数据库中确定了 2010 年至 2015 年间诊断的所有 STS 患者。研究了首发时脑转移的发生率和组织学亚型中脑转移发生率较高的情况。此外，还检查了脑转移的危险因素。
结果
共纳入 26676 例患者进行分析，其中 162 例（0.6%）发生脑转移。腺泡状软组织肉瘤（6.3%）、恶性血管内皮细胞瘤（3.1%）和恶性神经鞘瘤（2.6%）显示出较高的脑转移发生率。深在性肿瘤、躯干肿瘤和组织学高级别肿瘤倾向于显示较高的脑转移发生率。
结论
脑转移的危险因素是深部位置、躯干发育和组织学高级别肿瘤，或特定的组织学亚型。
Zotero 插件