肉瘤患者的脑转移：组织学亚型、临床特征及预后分析
Brain metastasis in patients with sarcoma: an analysis of histological subtypes, clinical characteristics, and outcomes.
作者信息
Yoshida S, Morii K, Watanabe M, Saito T
机构信息
Department of Neurosurgery, Niigata Cancer Center Hospital, Niigata, Japan.
出版信息
Surg Neurol. 2000 Aug;54(2):160-4. doi: 10.1016/s0090-3019(00)00293-7.
BACKGROUND
The clinical characteristics of brain metastasis from sarcoma are not well known. We examined the incidence and the characteristics of brain metastasis in patients with sarcomas.
METHODS
All sarcoma patients treated at our institution from 1975 to 1998 were reviewed for brain metastasis. Diagnosis of the primary tumor was confirmed histologically, and brain metastasis was confirmed using computed tomographic (CT) brain scan.
RESULTS
Brain metastasis was found in 27 (5.6%) of 480 patients with systemic sarcoma (7.2% soft part sarcoma, 3.5% bone sarcoma, 15.1% distant metastasis). Of these 27 sarcoma patients with brain metastases, lung metastasis occurred in 16 patients (59.3%). Out of 10 patients surgically treated, 8 patients survived more than 16 months. Median survival period after craniotomy was 25.4 months.
CONCLUSIONS
We recommend aggressive treatment for those patients with brain metastases whose performance scores are over 70.
背景
肉瘤脑转移的临床特征尚不明确。我们研究了肉瘤患者脑转移的发生率及特征。
方法
回顾性分析1975年至1998年在我院接受治疗的所有肉瘤患者的脑转移情况。原发肿瘤的诊断经组织学证实，脑转移通过头颅计算机断层扫描（CT）确诊。
结果
480例全身性肉瘤患者中有27例（5.6%）发生脑转移（软组织肉瘤为7.2%，骨肉瘤为3.5%，远处转移为15.1%）。在这27例发生脑转移的肉瘤患者中，16例（59.3%）出现肺转移。10例接受手术治疗的患者中，8例存活超过16个月。开颅术后的中位生存期为25.4个月。
结论
我们建议对那些功能状态评分超过70分的脑转移患者采取积极治疗。
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