Department of Clinical Biomechanics, Keio University, 35 Shinano-machi, Shinjuku-ku, Tokyo, 160-8582, Japan.
Department of Orthopaedic Surgery, Ogikubo Hospital, 3-1-24 Imagawa, Suginami-ku, Tokyo, 167-0035, Japan.
Sci Rep. 2021 Nov 3;11(1):21628. doi: 10.1038/s41598-021-00874-7.
The present study aimed to quantify and visualize the degenerative patterns of the distal tibia and fibula due to ankle osteoarthritis (OA). We analyzed differences in tibial and fibular surface deviation between sides of patients with unilateral varus ankle OA (medial talar tilt > 4°) by registering each surface model to the mirror image of corresponding bone. Computed tomography images of both feet of 33 patients (OA: 22, control: 11) were examined. Statistically significant surface depression of approximately 2.5 mm on the anterior articular surface of the medial malleolus, and surface elevation of approximately 1 mm on the anterodistal edge of the tibiofibular joint and the lateral malleolus were observed in OA patients. These bone degenerations were found to be correlated with those on the other side of the ankle joint, the medial margin of the talar trochlea and the lateral articular surface of the talus, respectively. In contrast, the amount of bone depression on the plafond was smaller than previously anticipated. Such quantitative information about stereotypical patterns of bone degeneration in ankle OA would contribute to better understanding of the development of ankle OA and possible therapeutic interventions.
本研究旨在定量和可视化踝关节骨关节炎（OA）导致的胫骨和腓骨远端的退行性变化模式。我们通过将每个表面模型与相应骨骼的镜像进行配准，分析了单侧内翻踝关节 OA（距骨内倾斜度>4°）患者两侧胫骨和腓骨表面偏差的差异。检查了 33 名患者（OA：22 名，对照组：11 名）双脚的 CT 图像。在 OA 患者中，观察到距骨内踝前关节面约 2.5mm 的表面凹陷，以及胫腓关节和外踝前远端边缘约 1mm 的表面隆起。这些骨退变分别与踝关节另一侧、距骨滑车的内侧缘和距骨的外侧关节面的骨退变相关。相比之下，距骨底的骨凹陷量小于预期。这种关于踝关节 OA 骨退行性变典型模式的定量信息将有助于更好地理解踝关节 OA 的发展和可能的治疗干预。
