Thota Vihitha, Konduru Sudheer, Mulla Sana, Hossain Samia, Thota Manaswitha, Thirumaran Rajesh
Department of Internal Medicine, Mercy Catholic Medical Center, Darby, Pennsylvania.
School of Medicine, Virginia Commonwealth University, Richmond, Virginia.
Proc (Bayl Univ Med Cent). 2021 Jun 15;34(6):718-720. doi: 10.1080/08998280.2021.1934346. eCollection 2021.
A commonly seen phenomenon in the hospital and critical care setting is anaphylaxis. This acute systemic inflammatory reaction can lead to anaphylactic shock in severe cases and potentially be fatal. The role of platelets in anaphylactic reactions is not well established; however, platelets, among other mediators such as platelet-activating factor, have been shown to promote a prothrombotic state shortly after an acute hypersensitivity reaction. In addition, the aggregation of platelets promoted by platelet-activating factor and other mediators can also lead to thrombocytopenia. We present a case of a 57-year-old woman who developed severe anaphylaxis while receiving chemotherapy with paclitaxel suspended in Cremophor, a well-known allergen. She was profoundly thrombocytopenic following the reaction and was treated with therapeutic anticoagulation, with no thrombus formation.
在医院和重症监护环境中常见的一种现象是过敏反应。这种急性全身性炎症反应在严重情况下可导致过敏性休克，并可能致命。血小板在过敏反应中的作用尚未完全明确；然而，血小板与其他介质如血小板活化因子一样，已被证明在急性过敏反应后不久会促进血栓前状态。此外，血小板活化因子和其他介质促进的血小板聚集也可导致血小板减少。我们报告一例57岁女性病例，该患者在接受用聚氧乙烯蓖麻油混悬的紫杉醇化疗时发生严重过敏反应，聚氧乙烯蓖麻油是一种知名的过敏原。反应后她出现严重血小板减少，并接受了抗凝治疗，未形成血栓。
