Parashar Samiksha, Karthik A R, Gupta Ravi, Malviya Deepak
Department of Anaesthesiology and Critical Care, Dr Ram Manohar Lohia Institute of Medical Sciences, Lucknow, Uttar Pradesh, India.
Department of Oncoanaesthesia and Palliative Medicine, BRAIRCH, AIIMS, Delhi.
Indian J Crit Care Med. 2021 Aug;25(8):906-916. doi: 10.5005/jp-journals-10071-23910.
Awake proning is an intervention that is being advocated for COVID-19 patients and has been suggested to improve the oxygenation, thereby decreasing oxygen requirements. We performed this systematic review with the aim of appraising the latest published evidence on the clinical effectiveness of awake proning in COVID-19 patients. PubMed, EMBASE, The Cochrane Central Register of Controlled Trials (CENTRAL), Web of Science, Google Scholar, and one trial registry were searched until September 23, 2020, for studies on the use of awake proning for nonintubated COVID-19 patients. Published or in-press peer-reviewed randomized control trials, case-control trials, and prospective or retrospective cohort studies in English language only were sought, assessing the effectiveness of awake proning for nonintubated patients diagnosed with COVID-19. We included 21 published studies (19 single arm and 2 with comparison group). Twenty-three registered clinical trials were identified. No randomized clinical trial has been published so far. Awake proning is probably safe and effective in enhancing oxygenation in nonintubated COVID-19 patients; however, there is insufficient evidence. Further high-quality clinical trials are urgently needed to assess the effectiveness of awake proning on a variety of patient-centered outcomes. Parashar S, Karthik AR, Gupta R, Malviya D. Awake Proning for Nonintubated Adult Hypoxic Patients with COVID-19: A Systematic Review of the Published Evidence. Indian J Crit Care Med 2021;25(8):906-916.
清醒俯卧位是一种正在被提倡用于新冠病毒肺炎患者的干预措施，有人认为它可以改善氧合，从而降低氧气需求。我们进行了这项系统评价，目的是评估关于清醒俯卧位对新冠病毒肺炎患者临床有效性的最新发表证据。检索了PubMed、EMBASE、Cochrane对照试验中心注册库（CENTRAL）、科学网、谷歌学术以及一个试验注册库，直至2020年9月23日，查找关于清醒俯卧位用于未插管新冠病毒肺炎患者的研究。仅检索发表的或即将发表的、经同行评审的随机对照试验、病例对照试验以及仅用英文发表的前瞻性或回顾性队列研究，评估清醒俯卧位对诊断为新冠病毒肺炎的未插管患者的有效性。我们纳入了21项已发表研究（19项单臂研究和2项有比较组的研究）。确定了23项注册临床试验。目前尚无随机临床试验发表。清醒俯卧位可能对提高未插管新冠病毒肺炎患者的氧合是安全有效的；然而，证据不足。迫切需要进一步的高质量临床试验来评估清醒俯卧位对各种以患者为中心结局的有效性。Parashar S、Karthik AR、Gupta R、Malviya D。清醒俯卧位用于未插管的新冠病毒肺炎成年低氧患者：已发表证据的系统评价。《印度重症监护医学杂志》2021年；25(8):906 - 916。
