Pett Ryan G, Silva Francisco, D'Amico Colleen
and are Clinical Pharmacists at Portland Area Indian Health Service in Washington.
Fed Pract. 2021 Jun;38(6):276-281. doi: 10.12788/fp.0135.
Many antibiotics prescribed in an outpatient setting may be inappropriate, and by some estimates, half of the antibiotic prescriptions for acute bronchitis may be inappropriate. This quality improvement study aimed to decrease the rate of potentially inappropriate (not guideline concordant) antibiotic prescribing in acute bronchitis.
This program used an audit and feedback approach. Clinicians received education coupled with audit and feedback, which are components of the Centers of Disease Control and Prevention framework for an effective antimicrobial stewardship program. Antibiotic prescribing rates in patients with acute bronchitis without underlying chronic lung disease or evidence of bacterial infection were compared over two 9-month periods. The baseline period was October 1, 2017 to June 30, 2018 and the posteducation period was October 1, 2018 to June 30, 2019.
Potentially inappropriate antibiotic prescribing dropped from 75% (160/213) at baseline to 60% (107/177) posteducation (95% CI 0.05, 0.24; < .01, 2-sample binomial test). Rates were lower for 7 health care providers (HCPs), unchanged for 1 HCP, and slightly increased for 1 HCP between study periods ( = .02, Wilcoxon signed rank test for paired data).
Study findings show a decline in potentially inappropriate antibiotic prescribing and a resulting improvement in clinic antimicrobial stewardship efforts.
门诊开出的许多抗生素可能并不恰当,据一些估计,急性支气管炎的抗生素处方中有一半可能并不恰当。这项质量改进研究旨在降低急性支气管炎中潜在不恰当(不符合指南)抗生素处方的比例。
本项目采用审核与反馈方法。临床医生接受了教育,并结合审核与反馈,这些都是疾病控制与预防中心有效抗菌药物管理计划框架的组成部分。比较了两个9个月期间无潜在慢性肺病或细菌感染证据的急性支气管炎患者的抗生素处方率。基线期为2017年10月1日至2018年6月30日,教育后时期为2018年10月1日至2019年6月30日。
潜在不恰当抗生素处方率从基线时的75%(160/213)降至教育后的60%(107/177)(95%CI 0.05,0.24;P<0.01,双样本二项式检验)。研究期间,7名医疗保健提供者(HCP)的处方率降低,1名HCP的处方率不变,1名HCP的处方率略有上升(P=0.02,配对数据的Wilcoxon符号秩检验)。
研究结果表明,潜在不恰当抗生素处方率有所下降,临床抗菌药物管理工作也因此得到改善。