Zheng Zhong, Liu Chengqi, Shen Ying, Xia Liang, Xiao Lili, Sun Yuanyuan, Wang Hui, Chen Zhengnong, Wu Yaqin, Shi Haibo, Feng Yanmei, Yin Shankai
Department of Otolaryngology-Head and Neck Surgery, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.
Shanghai Key Laboratory of Sleep Disordered Breathing, Shanghai, China.
Front Neurol. 2021 Oct 18;12:747561. doi: 10.3389/fneur.2021.747561. eCollection 2021.
As a common otology emergency, sudden sensorineural hearing loss (SSNHL) has a great impact on quality of life. The diagnosis and treatment of SSNHL remain challenging. This study aims to identify and investigate the association of liver functions with SSNHL. A total of 135 SSNHL patients and 135 sex- and age-matched controls were prospectively enrolled. The baseline and clinical characteristics, along with liver function levels of participators, were collected. Linear correlation, logistic regression, and receiving operator characteristic curve analysis tests were applied to examine the association between liver function levels and SSNHL. There were no differences in baseline characteristics between SSNHL and control groups. The albumin (ALB) level of the SSNHL group was significantly lower than that in the control group ( < 0.001). The logistic regression showed that the low ALB level may be a predictive factor of SSNHL with an adjusted OR of 0.809 (95% CI, 0.742-0.882, < 0.001). By comparing the indicators of different prognosis groups, we found that the effective group had a significantly lower hearing impair onset and higher ALB ( = 0.001) and AGR ( = 0.003) levels than the ineffective group. Logistic regression revealed that the hearing level onset (OR, 0.976; 95% CI, 0.956-0.997; = 0.026) and ALB level (OR, 1.181; 95% CI, 1.071-1.301; = 0.001) showed strong associations with treatment outcome. Lower ALB levels, within the normal ranges, were associated with the occurrence and unfavorable outcome of SSNHL. However, further research on the underlying mechanisms needs to be conducted.
作为一种常见的耳科急症，突发性感音神经性听力损失（SSNHL）对生活质量有很大影响。SSNHL的诊断和治疗仍然具有挑战性。本研究旨在确定并调查肝功能与SSNHL之间的关联。前瞻性纳入了135例SSNHL患者和135例年龄及性别匹配的对照。收集了参与者的基线和临床特征以及肝功能水平。应用线性相关、逻辑回归和接受者操作特征曲线分析测试来检验肝功能水平与SSNHL之间的关联。SSNHL组和对照组的基线特征无差异。SSNHL组的白蛋白（ALB）水平显著低于对照组（<0.001）。逻辑回归显示，低ALB水平可能是SSNHL的一个预测因素，调整后的比值比为0.809（95%置信区间，0.742 - 0.882，<0.001）。通过比较不同预后组的指标，我们发现有效组的听力损害 onset 显著低于无效组，且ALB（=0.001）和AGR（=0.003）水平更高。逻辑回归显示，听力水平 onset（比值比，0.976；95%置信区间，0.956 - 0.997；=0.026）和ALB水平（比值比，1.181；95%置信区间，1.071 - 1.301；=0.001）与治疗结果密切相关。在正常范围内较低的ALB水平与SSNHL的发生和不良预后相关。然而，需要对潜在机制进行进一步研究。
