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激肽释放酶白细胞介素-26即使对多重耐药菌株也显示出即时抗菌作用。

The Kinocidin Interleukin-26 Shows Immediate Antimicrobial Effects Even to Multi-resistant Isolates.

作者信息

Hansen Bjoern-Thore, Maschkowitz Gregor, Podschun Rainer, Fickenscher Helmut

机构信息

Institute for Infection Medicine, Christian-Albrecht University of Kiel and University Hospital Schleswig-Holstein, Kiel, Germany.

出版信息

Front Microbiol. 2021 Oct 18;12:757215. doi: 10.3389/fmicb.2021.757215. eCollection 2021.

DOI:10.3389/fmicb.2021.757215
PMID:34733265
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8558509/
Abstract

The cationic proinflammatory cytokine Interleukin 26 (IL-26) shows antibacterial activity and inhibits the replication of cytomegalovirus and hepatitis C virus. This study evaluates the early microbicidal activities of IL-26 against major bacterial species including multi-resistant variants and . Recombinant IL-26 was bacterially expressed and studied for its microbicidal effects in culture. We show that IL-26 has strong 90% bactericidal activities against , and . Similarly, IL-26 sensitivity was also detectable in vancomycin-resistant Enterococcus species, methicillin-resistant , and carbapenem-resistant clinical isolates. Additionally, a significant, albeit weak fungicidal effect against was observed. Activities against , and were not detectable. The proinflammatory cytokine and kinocidin IL-26 shows strong bactericidal activities against and, almost selectively, against Gram-positive bacteria.

摘要

阳离子促炎细胞因子白细胞介素26（IL-26）具有抗菌活性，并能抑制巨细胞病毒和丙型肝炎病毒的复制。本研究评估了IL-26对包括多重耐药变体在内的主要细菌种类的早期杀菌活性。重组IL-26通过细菌表达，并在培养中研究其杀菌作用。我们发现IL-26对[具体细菌1]、[具体细菌2]和[具体细菌3]具有很强的90%杀菌活性。同样，在耐万古霉素肠球菌、耐甲氧西林[具体细菌4]和耐碳青霉烯[具体细菌5]临床分离株中也可检测到IL-26敏感性。此外，观察到对[具体真菌]有显著但较弱的杀真菌作用。未检测到对[具体细菌6]、[具体细菌7]和[具体细菌8]的活性。促炎细胞因子和亲嗜素IL-26对[具体细菌9]以及几乎选择性地对革兰氏阳性菌具有很强的杀菌活性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/229a/8558509/428e91c6e01d/fmicb-12-757215-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/229a/8558509/4ab0b7815fbf/fmicb-12-757215-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/229a/8558509/68d86a9d7a52/fmicb-12-757215-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/229a/8558509/428e91c6e01d/fmicb-12-757215-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/229a/8558509/4ab0b7815fbf/fmicb-12-757215-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/229a/8558509/68d86a9d7a52/fmicb-12-757215-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/229a/8558509/428e91c6e01d/fmicb-12-757215-g003.jpg

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