Internal Medicine Department, Habib Thameur Hospital, Faculty of Medicine of Tunis, University Tunis El Manar, Tunis, Tunisia.
Department of Dermatology, Habib Thameur Hospital, Faculty of Medicine of Tunis, University Tunis El Manar, Tunis, Tunisia.
Pan Afr Med J. 2021 Sep 3;40:13. doi: 10.11604/pamj.2021.40.13.19146. eCollection 2021.
to describe the epidemiological, clinical, therapeutic and evolving characteristics of Behçet´s disease and identify prognostic factors.
we have realized a retrospective, single-center study, conducted over a period of 26 years and including 130 patients presenting Behçet´s disease and hospitalized in an Internal Medicine Department.
the mean age of the Behçet´s disease at onset was 30.3 ±8.8 years and that at diagnosis was 34.6 ±9.4 years. The sex ratio (male/female) was 2.5. The mean delay of diagnosis was 53.5 months. Oral aphthosis was constant. The frequency of the manifestations was: genital aphtosis 71.5%, pseudofolliculitis 84.6%, erythema nodosum 11.5%, positive pathergy test 50%, ocular disease 36.9%, venous thrombosis 30%, arterial disease 4.6%, joint damage 30.8%, neurological disease 19.2% and digestive disease 0.8%. The male gender was significantly associated with ocular involvement (p =0.02), venous disease (p =0.01) and occurrence of relapses (p =0.01). The mean follow up was 68.5 ± 77.3 months. The poor survival prognostic factors were male gender, ocular involvement, venous disease, cardiovascular disease, a duration of follow up ≤12 months and a diagnostic delay ≤ 24 months. improving the prognosis of Behçet´s disease requires a shortening of the time to diagnosis, multidisciplinary collaboration, intensive treatment of functional threats, regular monitoring, and patient adherence.
描述贝切特病的流行病学、临床、治疗和演变特征，并确定预后因素。
我们进行了一项回顾性、单中心研究，历时 26 年，共纳入 130 例在我院内科住院的贝切特病患者。
贝切特病的发病年龄平均为 30.3 ±8.8 岁，确诊年龄平均为 34.6 ±9.4 岁。男女比例为 2.5。平均诊断延迟时间为 53.5 个月。口腔阿弗他溃疡为常见表现。其他表现的频率如下：生殖器阿弗他溃疡 71.5%、假性毛囊炎 84.6%、结节性红斑 11.5%、帕特试验阳性 50%、眼部疾病 36.9%、静脉血栓形成 30%、动脉疾病 4.6%、关节损伤 30.8%、神经系统疾病 19.2%和消化系统疾病 0.8%。男性与眼部受累（p =0.02）、静脉疾病（p =0.01）和复发（p =0.01）显著相关。平均随访时间为 68.5 ± 77.3 个月。男性、眼部受累、静脉疾病、心血管疾病、随访时间≤12 个月和诊断延迟≤24 个月是预后不良的危险因素。改善贝切特病的预后需要缩短诊断时间、多学科合作、强化对功能威胁的治疗、定期监测和患者的依从性。
