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多个人类肿瘤病例分析揭示 PKP3 的致癌效应。

Analysis of Multiple Human Tumor Cases Reveals the Carcinogenic Effects of PKP3.

机构信息

The First Affiliated Hospital with Nanjing Medical University, Jiangsu Province Hospital, Nanjing 210029, China.

出版信息

J Healthc Eng. 2021 Oct 25;2021:9391104. doi: 10.1155/2021/9391104. eCollection 2021.

DOI:10.1155/2021/9391104
PMID:34733461
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8560240/
Abstract

Plakophilins (PKPs) act as a key regulator of different signaling programs and control a variety of cellular processes ranging from transcription, protein synthesis, growth, proliferation, and tumor development. The function and possible mechanism of PKP3 in ovarian cancer (OC) remain unknown. It is extremely important to investigate the expression and prognostic values of PKP3, as well as their possible mechanisms, and immune infiltration in OC. Therefore, in this paper we explored the potential oncogenic role of PKP3 in 33 tumors based on The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) datasets. The result outcomes showed that PKP3 is highly expressed in most cancers, and the expression level and prognosis of PKP3 showed little significance in cancer patients. Moreover, oncologists have found that members of the plakophilin family have different degrees of abnormality in ovarian cancer. PKP3 played a key part in carcinogenesis and aggressiveness of OC as well as malignant biological activity and can be used as a biomarker for early diagnosis and prognosis evaluation in OC.

摘要

plakophilins (PKPs) 作为不同信号通路的关键调节因子，控制着从转录、蛋白质合成、生长、增殖到肿瘤发生的各种细胞过程。PKP3 在卵巢癌 (OC) 中的功能和可能的机制尚不清楚。研究 PKP3 的表达和预后价值及其可能的机制，以及 OC 中的免疫浸润，这一点极其重要。因此，在本文中，我们基于癌症基因组图谱 (TCGA) 和基因表达综合数据库 (GEO) 数据集，探讨了 PKP3 在 33 种肿瘤中的潜在致癌作用。结果表明，PKP3 在大多数癌症中高表达，而 PKP3 的表达水平和预后在癌症患者中意义不大。此外，肿瘤学家发现 plakophilin 家族成员在卵巢癌中存在不同程度的异常。PKP3 在 OC 的发生和侵袭性以及恶性生物学活性中起着关键作用，可作为 OC 早期诊断和预后评估的生物标志物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/be51/8560240/91847a662eb4/JHE2021-9391104.011.jpg
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