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白细胞介素4启动子-589C/T基因多态性与哮喘风险：一项系统评价和荟萃分析。

Polymorphisms in the interleukin 4 promoter -589C/T gene and the risk of asthma: a systematic review and meta-analysis.

作者信息

Zhu Lu, Liu Tao, Wang Li, Li Qiwei, Wu Yong, Liu Bin

机构信息

Department of Pediatrics, The Affiliated Hospital of Southwest Medical University, Luzhou, China.

Sichuan Clinical Research Center for Birth Defects, Luzhou, China.

出版信息

Transl Pediatr. 2021 Sep;10(9):2355-2365. doi: 10.21037/tp-21-419.

DOI:10.21037/tp-21-419
PMID:34733676
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8506068/
Abstract

BACKGROUND

To identify the association between polymorphisms in the interleukin 4 (IL-4) promoter -589C/T gene and the risk of asthma.

METHODS

The databases of PubMed, Embase, Cochrane Library, China National Knowledge Infrastructure (CNKI), Wanfang, Chongqing VIP (CQVIP), and Chinese Biomedical Literature (CBM) were searched and appropriate journal articles on the association between polymorphisms in the IL-4 promoter -589C/T gene and the risk of asthma were retrieved from establishment of the database to April 2021. All relevant randomized controlled trials (RCTs) were included, to the exclusion of duplicate publications, studies with no whole composition, imperfect information or inability to extract data, animal experiments and reviews, and systematic reviews. The software Review manager 5.3 was used to analyze the data.

RESULTS

Literature search led to retrieving of 16 publications containing 3181 cases and 3786 controls. The results show that CT, CC, and T gene polymorphisms were risk factors for asthma [odds ratio (OR) =1.05, 95% confidence interval (CI): 0.89-1.24; OR =1.04, 95% CI: 0.85-1.27; OR =1.98, 95% CI: 1.54-2.53]. Ethnic subgroup analysis showed that genotype CT was associated with the risk of asthma in the Asian population (OR =1.75, 95% CI: 1.01-3.05).

DISCUSSION

Through the study of IL-4 (C-590T) gene polymorphism, it was found that CT, TT, and T gene polymorphism were risk factors for asthma, and the results suggested that this locus polymorphism was related to the risk of asthma. The results of subgroup analysis showed that CC and T gene polymorphisms were risk factors for asthma. Thus, IL-4(C-590T) may be the susceptibility gene of asthma.

摘要

背景

确定白细胞介素4（IL-4）启动子-589C/T基因多态性与哮喘风险之间的关联。

方法

检索PubMed、Embase、Cochrane图书馆、中国知网（CNKI）、万方、重庆维普（CQVIP）和中国生物医学文献数据库（CBM），从数据库建立至2021年4月检索关于IL-4启动子-589C/T基因多态性与哮喘风险关联的相关期刊文章。纳入所有相关随机对照试验（RCT），排除重复发表的文献、无完整内容、信息不完整或无法提取数据的研究、动物实验和综述以及系统评价。使用Review manager 5.3软件分析数据。

结果

文献检索得到16篇出版物，包含3181例病例和3786例对照。结果显示，CT、CC和T基因多态性是哮喘的危险因素[比值比（OR）=1.05，95%置信区间（CI）：0.89 - 1.24；OR =1.04，95%CI：0.85 - 1.27；OR =1.98，95%CI：1.54 - 2.53]。种族亚组分析显示，基因型CT与亚洲人群哮喘风险相关（OR =1.75，95%CI：1.01 - 3.05）。

讨论

通过对IL-4（C-590T）基因多态性的研究发现，CT、TT和T基因多态性是哮喘的危险因素，结果表明该位点多态性与哮喘风险相关。亚组分析结果显示，CC和T基因多态性是哮喘的危险因素。因此，IL-4（C-590T）可能是哮喘的易感基因。

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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5c3d/8506068/1ae609ac5c50/tp-10-09-2355-f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5c3d/8506068/ac9c1a724a96/tp-10-09-2355-f7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5c3d/8506068/dba01bf90624/tp-10-09-2355-f8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5c3d/8506068/c228d715a430/tp-10-09-2355-f9.jpg
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