Department of Health Education and Health Promotion, Faculty of Health, Tabriz University of Medical Sciences, Tabriz, Iran.
Research Center for Advanced Technologies in Cardiovascular Medicine, Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran.
BMC Immunol. 2020 Oct 21;21(1):55. doi: 10.1186/s12865-020-00384-7.
Numerous investigations have previously evaluated the association of interleukin (IL) 4 gene polymorphisms and the risk of asthma, conferring inconsistent results. To resolve the incongruent outcomes yielded from different single studies, we conducted the most up-to-date meta-analysis of IL4 gene -589C/T (rs2243250) polymorphism and susceptibility to asthma.
A systematic literature search was performed in ISI web of science, Scopus, Medline/PubMed databases prior to September 2020, and the pooled odds ratio (OR) and their corresponding 95% CI were calculated to determine the association strength.
Literature search led to retrieving of 49 publications (55 case-control studies) containing 9572 cases and 9881 controls. It was revealed that IL4 gene -589C/T polymorphism increased the risk of asthma across all genetic models, including dominant model (OR = 1.22), recessive model (OR = 1.17), allelic model (OR = 1.21), and TT vs. CC model (OR = 1.34), but not the CT vs. TT model. The subgroup analysis by age indicated that IL4 gene -589C/T polymorphism was significantly associated with asthma risk in both pediatrics and adults. Additionally, the subgroup analysis by ethnicity revealed significant association in Asian, American, and Europeans. Finally, subgroup analysis by East Asian and non-East Asian populations indicated significant associations.
The current meta-analysis revealed that IL4 gene -589C/T polymorphism was a susceptibility risk in both pediatrics and adults in the whole and different ethnic groups.
先前已有许多研究评估了白细胞介素（IL）4 基因多态性与哮喘风险之间的关联，但结果并不一致。为了解决不同单项研究结果不一致的问题，我们对 IL4 基因-589C/T（rs2243250）多态性与哮喘易感性进行了最新的荟萃分析。
我们在 ISI web of science、Scopus、Medline/PubMed 数据库中进行了系统的文献检索，检索时间截至 2020 年 9 月，计算了合并的比值比（OR）及其相应的 95%置信区间，以确定关联强度。
文献检索共检索到 49 篇文献（55 项病例对照研究），包含 9572 例病例和 9881 例对照。结果表明，IL4 基因-589C/T 多态性在所有遗传模型中均增加了哮喘的风险，包括显性模型（OR=1.22）、隐性模型（OR=1.17）、等位基因模型（OR=1.21）和 TT 与 CC 模型（OR=1.34），但 CT 与 TT 模型除外。按年龄进行的亚组分析表明，IL4 基因-589C/T 多态性与儿科和成人的哮喘风险显著相关。此外，按种族进行的亚组分析表明，亚洲、美洲和欧洲人群均存在显著关联。最后，东亚和非东亚人群的亚组分析表明存在显著关联。
本荟萃分析表明，IL4 基因-589C/T 多态性在儿科和成人以及不同种族群体中均为哮喘的易感风险因素。
