Dai Qingqing, Ye Ming, Tang Zhiqiang, Yu Kaijiang, Gao Yang, Yang Zhenyu, Zheng Junbo, Zuo Shu, Liu Yan, Xie Fengjie, Han Qiuyuan, He Hua, Wang Hongliang
Department of Critical Care Medicine, the Second Affiliated Hospital of Harbin Medical University, Harbin, China.
Department of Critical Care Medicine, the First Affiliated Hospital of Harbin Medical University, Harbin, China.
Ann Transl Med. 2021 Sep;9(18):1446. doi: 10.21037/atm-21-3912.
The rapid spread of coronavirus disease-19 (COVID-19) poses a global health emergency, and cases entering China from Russia are quite diverse. This study explored and compared the clinical characteristics and outcomes of severe and critically ill COVID-19 patients from Russia with and without influenza A infection, treated in a northern Chinese hospital (Russia imported patients).
A total of 32 severe and critically ill Russia-imported COVID-19 patients treated in the Heilongjiang Imported Severe and Critical COVID-19 Treatment Center from April 6 to May 11, 2020 were included, including 8 cases (group A) with and 24 cases (group B) without influenza A infection. The clinical characteristics of each group were compared, including prolonged hospital stay, duration of oxygen therapy, time from onset to a negative SARS-CoV-2 qRT-PCR RNA (T) result, and duration of bacterial infection.
The results showed that blood group, PaO/FiO, prothrombin time (PT), prothrombin activity (PTA), computed tomography (CT) score, hospital stay, duration of oxygenation therapy, T, and duration of bacterial infection were statistically different between the two groups (P<0.05). Multivariant regression analysis showed that the Sequential Organ Failure Assessment (SOFA) score, C-reactive protein (CRP), and influenza A infection were factors influencing hospital stay; SOFA score, CRP, and CT score were factors influencing the duration of oxygenation therapy; PaO/FiO, platelet count (PLT), and CRP were factors influencing T; and gender, SOFA score, and influenza A infection were factors influencing the duration of bacterial infection.
Influenza A infection is common in Russia-imported COVID-19 patients, which can prolong the hospital stay and duration of bacterial infection. Routinely screening and treating influenza A should be conducted early in such patients.
新型冠状病毒肺炎（COVID-19）的迅速传播构成了全球卫生紧急事件，从俄罗斯输入中国的病例情况颇为多样。本研究探讨并比较了在中国北方一家医院接受治疗的合并或未合并甲型流感感染的俄罗斯输入型重症及危重症COVID-19患者的临床特征及预后情况（俄罗斯输入患者）。
纳入2020年4月6日至5月11日在黑龙江省输入型重症及危重症COVID-19救治中心接受治疗的32例俄罗斯输入型重症及危重症COVID-19患者，其中合并甲型流感感染的8例（A组），未合并甲型流感感染的24例（B组）。比较两组的临床特征，包括住院时间延长、氧疗时间、从发病到严重急性呼吸综合征冠状病毒2定量逆转录聚合酶链反应（SARS-CoV-2 qRT-PCR）RNA检测结果呈阴性的时间（T）以及细菌感染持续时间。
结果显示，两组之间血型、动脉血氧分压/吸氧浓度（PaO/FiO）、凝血酶原时间（PT）、凝血酶原活动度（PTA）、计算机断层扫描（CT）评分、住院时间、氧疗持续时间、T以及细菌感染持续时间存在统计学差异（P<0.05）。多变量回归分析显示，序贯器官衰竭评估（SOFA）评分、C反应蛋白（CRP）以及甲型流感感染是影响住院时间的因素；SOFA评分、CRP以及CT评分是影响氧疗持续时间的因素；PaO/FiO、血小板计数（PLT）以及CRP是影响T的因素；性别、SOFA评分以及甲型流感感染是影响细菌感染持续时间的因素。
甲型流感感染在俄罗斯输入型COVID-19患者中较为常见，可延长住院时间及细菌感染持续时间。对此类患者应尽早进行甲型流感的常规筛查及治疗。
