ABO 血型分布与 COVID-19 患者临床特征的关系。
Relationship between ABO blood group distribution and clinical characteristics in patients with COVID-19.
机构信息
Department of Radiology, The First Hospital of Changsha, Changsha, Hunan 410011, China.
Department of Nephrology, The Third Xiangya Hospital, Central South University, Changsha, Hunan 410013, China.
出版信息
Clin Chim Acta. 2020 Oct;509:220-223. doi: 10.1016/j.cca.2020.06.026. Epub 2020 Jun 17.
OBJECTIVE
To explore ABO blood group distribution and clinical characteristics in patients with COVID-19.
METHODS
The clinical data of 187 patients with COVID-19 seen between January 20, 2020 and March 5, 2020 at the First Hospital of Changsha were retrospectively analyzed. The differences in the ABO blood group distribution between COVID-19 patients and the control group (1991 cases) were analyzed. The relationship between blood type and clinical characteristics was analyzed.
RESULTS
Of the 187 patients with COVID-19, 69 had type A (36.90%), 63 had type B (33.69%), 41 had type O (21.92%), and 14 had type AB blood (7.49%). The proportion of patients with type A blood in the COVID-19 group was significantly higher than that in the control group (36.90% vs. 27.47%, P = 0.006), while the proportion of patients with type O blood in the COVID-19 group was significantly lower than that in the control group (21.92% vs. 30.19%, P = 0.018). The risk of COVID-19 was higher for individuals with blood group A than for those with blood group O (OR = 1.849, 95% CI = 1.228-2.768, P = 0.003). The risk of COVID-19 was higher for patients with blood group A than for those with a blood group other than A (OR = 1.544, 95% CI = 1.122-2.104, P = 0.006). Patients with blood group O had a lower risk of COVID-19 than non-O blood group patients (OR = 0.649, 95% CI = 0.457-0.927, P = 0.018). The ABO blood group distribution was related to COVID-19 status.
CONCLUSIONS
Patients with blood group A had an increased risk for infection with SARS-CoV-2, whereas blood group O was associated with a decreased risk, indicating that certain ABO blood groups were correlated with SARS-CoV-2 susceptibility. Blood type was related to some clinical characteristics of patients with COVID-19.
目的
探讨 COVID-19 患者的 ABO 血型分布及临床特征。
方法
回顾性分析 2020 年 1 月 20 日至 3 月 5 日在长沙市第一医院就诊的 187 例 COVID-19 患者的临床资料，分析 COVID-19 患者与对照组（1991 例）的 ABO 血型分布差异，分析血型与临床特征的关系。
结果
187 例 COVID-19 患者中，A型 69 例（36.90%），B 型 63 例（33.69%），O 型 41 例（21.92%），AB 型 14 例（7.49%）。COVID-19 组 A 型患者比例明显高于对照组（36.90%比 27.47%，P=0.006），O 型患者比例明显低于对照组（21.92%比 30.19%，P=0.018）。与 O 型血相比，A 型血个体患 COVID-19 的风险更高（OR=1.849，95%CI=1.2282.768，P=0.003）。与非 A 型血相比，A 型血患者患 COVID-19 的风险更高（OR=1.544，95%CI=1.1222.104，P=0.006）。与非 O 型血患者相比，O 型血患者患 COVID-19 的风险更低（OR=0.649，95%CI=0.457~0.927，P=0.018）。ABO 血型分布与 COVID-19 状态相关。
结论
A 型血患者感染 SARS-CoV-2 的风险增加，而 O 型血与感染风险降低相关，表明某些 ABO 血型与 SARS-CoV-2 易感性相关。血型与 COVID-19 患者的某些临床特征有关。
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