Zhang Lan, Wang Xi, Huang Congxin
Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, China.
Cardiovascular Research Institute, Wuhan University, Wuhan, China.
Ann Transl Med. 2021 Sep;9(18):1486. doi: 10.21037/atm-21-4483.
This review summarizes the advances in the study of ncRNAs and atrial remodeling mechanisms to explore potential therapeutic targets and strategies for AF.
Atrial fibrillation (AF) is one of the most common arrhythmias, and its morbidity and mortality rates are gradually increasing. Non-coding ribonucleic acid RNAs (ncRNAs) are transcribed from the genome and do not have the ability to be translated into proteins. A growing body of evidence has shown ncRNAs are extensively involved in the pathophysiological processes underlying AF. However, the precise molecular mechanisms of these associations have not been fully elucidated. Atrial remodeling plays a key role in the occurrence and development of AF, and includes electrical remodeling, structural remodeling, and autonomic nerve remodeling. Research has shown that ncRNA expression is altered in the plasma and tissues of AF patients that mediate cardiac excitation and arrhythmia, and is closely related to atrial remodeling.
Literatures about ncRNAs and atrial fibrillation were extensively reviewed to discuss and analyze.
The biology of ncRNAs represents a relatively new field of research and is still in an emerging stage. Recent studies have laid a foundation for understanding the molecular mechanisms of AF, future studies aimed at identifying how ncRNAs act on atrial fibrillation to provide potentially promising therapeutic targets for the treatment of atrial fibrillation.
本综述总结非编码RNA（ncRNAs）与心房重构机制的研究进展，以探索心房颤动（AF）潜在的治疗靶点和策略。
心房颤动（AF）是最常见的心律失常之一，其发病率和死亡率正在逐渐上升。非编码核糖核酸（ncRNAs）由基因组转录而来，不具备翻译成蛋白质的能力。越来越多的证据表明，ncRNAs广泛参与AF的病理生理过程。然而，这些关联的确切分子机制尚未完全阐明。心房重构在AF的发生和发展中起关键作用，包括电重构、结构重构和自主神经重构。研究表明，AF患者血浆和组织中的ncRNA表达发生改变，其介导心脏兴奋和心律失常，且与心房重构密切相关。
广泛查阅有关ncRNAs与心房颤动的文献进行讨论和分析。
ncRNAs生物学是一个相对较新的研究领域，仍处于起步阶段。近期研究为理解AF的分子机制奠定了基础，未来的研究旨在确定ncRNAs如何作用于心房颤动，为心房颤动的治疗提供潜在的、有前景的治疗靶点。
