Reis-Ferreira Ana, Neto-Mendes Joana, Brás-Silva Carmen, Lobo Luís, Fontes-Sousa Ana Patrícia
Hospital Veterinário do Porto, Travessa Silva Porto 174, 4250-475 Porto, Portugal.
ICBAS-UP, Instituto de Ciências Biomédicas Abel Salazar, Universidade do Porto, Rua Jorge de Viterbo Ferreira 228, 4050-313 Porto, Portugal.
Vet Sci. 2022 Sep 28;9(10):533. doi: 10.3390/vetsci9100533.
Over the last years, the importance of microRNAs (miRNAs) has increasingly been recognised. Each miRNA is a short sequence of non-coding RNA that influences countless genes' expression and, thereby, contributes to several physiological pathways and diseases. It has been demonstrated that miRNAs participate in the development of many cardiovascular diseases (CVDs). This review synopsises the most recent studies emphasising miRNA's influence in several CVDs affecting dogs and cats. It provides a concise outline of miRNA's biology and function, the diagnostic potential of circulating miRNAs as biomarkers, and their role in different CVDs. It also discusses known and future roles for miRNAs as potential clinical biomarkers and therapeutic targets. So, this review gives a comprehensive outline of the most relevant miRNAs related to CVDs in Veterinary Medicine.
在过去几年中，微小RNA（miRNA）的重要性日益得到认可。每个miRNA都是一段短的非编码RNA序列，它影响无数基因的表达，从而参与多种生理途径和疾病的发生。已证实miRNA参与多种心血管疾病（CVD）的发展。本综述总结了最近的研究，强调了miRNA对影响犬猫的几种CVD的影响。它简要概述了miRNA的生物学和功能、循环miRNA作为生物标志物的诊断潜力及其在不同CVD中的作用。它还讨论了miRNA作为潜在临床生物标志物和治疗靶点的已知及未来作用。因此，本综述全面概述了兽医学中与CVD相关的最相关miRNA。
