Song Yang, Zhang Ning, Yu Yue
Department of Rheumatology and Immunology, Shengjing Hospital of China Medical University, Shenyang 110004, Liaoning Province, China.
Department of Thoracic Surgery, Shengjing Hospital of China Medical University, Shenyang 110004, Liaoning Province, China.
World J Clin Cases. 2021 Oct 16;9(29):8831-8838. doi: 10.12998/wjcc.v9.i29.8831.
Eosinophilic fasciitis (EF) is a rare disease characterized by inflammation of the fascia with immune system involvement. Failure to promptly diagnose and treat this disease can seriously affect the quality of life of patients. However, no clear and uniform criteria for diagnosis and treatment exist.
In this paper, we report two cases of EF, both of which showed symmetrical limb swelling and rigidity, increased eosinophils in the peripheral blood and bone marrow, increased red blood cell sedimentation rate, increased antinuclear antibody titer, and pathological changes in the tissues such as eosinophil and lymphocyte infiltration. Both patients were treated with hormones and cyclosporine, and showed significant improvements in their conditions.
EF is an autoimmune disease causing swelling and sclerosis of the fascia and eosinophilia. It is diagnosable by magnetic resonance imaging, positron emission tomography-computed tomography, blood routine tests, and bone marrow puncture. Glucocorticoids and immunosuppressants are effective treatments.
嗜酸性筋膜炎（EF）是一种罕见疾病，其特征为筋膜炎症伴免疫系统受累。未能及时诊断和治疗该疾病会严重影响患者的生活质量。然而，目前尚无明确统一的诊断和治疗标准。
在本文中，我们报告了两例嗜酸性筋膜炎病例，两例均表现为四肢对称性肿胀和僵硬、外周血及骨髓嗜酸性粒细胞增多、红细胞沉降率升高、抗核抗体滴度升高以及组织病理改变如嗜酸性粒细胞和淋巴细胞浸润。两名患者均接受了激素和环孢素治疗，病情均有显著改善。
嗜酸性筋膜炎是一种导致筋膜肿胀和硬化以及嗜酸性粒细胞增多的自身免疫性疾病。可通过磁共振成像、正电子发射断层扫描 - 计算机断层扫描、血常规检查和骨髓穿刺进行诊断。糖皮质激素和免疫抑制剂是有效的治疗方法。
