Elanco Australasia Pty Ltd, 7 Eden Park Drive, Macquarie Park, New South Wales, 2113, Australia.
Invetus Pty Ltd, Yorklea, New South Wales, 2470, Australia.
Aust Vet J. 2022 Mar;100(3):83-89. doi: 10.1111/avj.13133. Epub 2021 Nov 3.
The objective of this study was to determine the repellency and efficacy of a 10% imidacloprid/4.5% flumethrin (Seresto , Elanco) collar over an 8-month period against the eastern paralysis tick (Ixodes holocyclus) on cats.
Two non-blinded, open gender, randomised, placebo-controlled pen studies were conducted, with 26 cats enrolled in each study. Prior to inclusion, cats were immunised with I. holocyclus holocyclotoxin. Cats were treated on Day 0 with either an imidacloprid/flumethrin or placebo collar. Tick infestations with 20 unfed adult female eastern paralysis ticks commenced on Day 7, and were repeated monthly for 8 months. Repellency was determined by comparing the mean number of attached ticks on imidacloprid/flumethrin treated cats, to placebo collar treated cats at 6 and 24 h post infestation. Efficacy was determined by comparing the mean number of live ticks on imidacloprid/flumethrin collar treated cats to placebo collar treated cats at 72 h post infestation.
Efficacy was 100% (P < 0.001) at 72 h, and repellency was greater than 96% (P < 0.001) at 24 h for every tick challenge in each of the two studies, from Day 7 to the final infestation at 8 months for imidacloprid/flumethrin collar treated cats.
In two pen studies, an imidacloprid/flumethrin collar controlled and repelled the eastern paralysis tick (I. holocyclus) on cats for 8-months. The marked repellency effect in addition to controlling tick paralysis would be beneficial in preventing tick bites and their sequelae.
本研究旨在确定 10%吡虫啉/4.5%氟氯氰菊酯（Seresto，Elanco）项圈在 8 个月内对猫的东部麻痹蜱（Ixodes holocyclus）的驱避和疗效。
进行了两项非盲、开放性别、随机、安慰剂对照的围栏研究，每研究纳入 26 只猫。纳入前，猫用 I. holocyclus holocyclotoxin 免疫。猫在第 0 天用吡虫啉/氟氯氰菊酯或安慰剂项圈处理。第 7 天开始，用 20 只未喂食的成年雌性东部麻痹蜱进行蜱虫感染，每月重复一次，共 8 个月。通过比较感染后 6 和 24 小时附着在吡虫啉/氟氯氰菊酯处理猫上的蜱的平均数量，来确定驱避效果。通过比较感染后 72 小时吡虫啉/氟氯氰菊酯项圈处理猫上的活蜱的平均数量和安慰剂项圈处理猫上的活蜱的平均数量，来确定疗效。
在两项研究中，从第 7 天到 8 个月的最后一次感染，在每个蜱虫挑战中，吡虫啉/氟氯氰菊酯项圈在 24 小时内的疗效为 100%（P<0.001），驱避率大于 96%（P<0.001）。
在两项围栏研究中，吡虫啉/氟氯氰菊酯项圈在 8 个月内控制和驱避了猫的东部麻痹蜱（I. holocyclus）。除了控制蜱瘫痪外，这种明显的驱避效果将有助于预防蜱叮咬及其后遗症。
